3dv2

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{{Seed}}
 
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[[Image:3dv2.png|left|200px]]
 
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==Crystal Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis==
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The line below this paragraph, containing "STRUCTURE_3dv2", creates the "Structure Box" on the page.
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<StructureSection load='3dv2' size='340' side='right'caption='[[3dv2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dv2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DV2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3dv2| PDB=3dv2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dv2 OCA], [https://pdbe.org/3dv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dv2 RCSB], [https://www.ebi.ac.uk/pdbsum/3dv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dv2 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dv2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dv2 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nicotinic acid mononucleotide adenylyltransferase (NaMNAT; EC 2.7.7.18) is the penultimate enzyme in the biosynthesis of NAD(+) and catalyzes the adenylation of nicotinic acid mononucleotide (NaMN) by ATP to form nicotinic acid adenine dinucleotide (NaAD). This enzyme is regarded as a suitable candidate for antibacterial drug development; as such, Bacillus anthracis NaMNAT (BA NaMNAT) was heterologously expressed in Escherichia coli for the purpose of inhibitor discovery and crystallography. The crystal structure of BA NaMNAT was determined by molecular replacement, revealing two dimers per asymmetric unit, and was refined to an R factor and R(free) of 0.228 and 0.263, respectively, at 2.3 A resolution. The structure is very similar to that of B. subtilis NaMNAT (BS NaMNAT), which is also a dimer, and another independently solved structure of BA NaMNAT recently released from the PDB along with two ligated forms. Comparison of these and other less related bacterial NaMNAT structures support the presence of considerable conformational heterogeneity and flexibility in three loops surrounding the substrate-binding area.
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===Crystal Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis===
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Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis.,Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt, 10):893-8. Epub 2008 Sep 30. PMID:18931430<ref>PMID:18931430</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18931430}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3dv2" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18931430 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18931430}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DV2 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV2 OCA].
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==Reference==
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<ref group="xtra">PMID:18931430</ref><references group="xtra"/>
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Nicotinate-nucleotide adenylyltransferase]]
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[[Category: Large Structures]]
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[[Category: Brouillette, C G.]]
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[[Category: Brouillette CG]]
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[[Category: Brouillette, W J.]]
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[[Category: Brouillette WJ]]
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[[Category: DeLucas, L J.]]
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[[Category: DeLucas LJ]]
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[[Category: Lu, S.]]
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[[Category: Lu S]]
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[[Category: McCombs, D P.]]
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[[Category: McCombs DP]]
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[[Category: Nagy, L.]]
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[[Category: Nagy L]]
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[[Category: Pruett, P S.]]
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[[Category: Pruett PS]]
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[[Category: Smith, C D.]]
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[[Category: Smith CD]]
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[[Category: Yang, Z.]]
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[[Category: Yang Z]]
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[[Category: Alpha and beta protein]]
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[[Category: Nad]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Pyridine nucleotide biosynthesis]]
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[[Category: Rossman fold]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:20:30 2009''
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Current revision

Crystal Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis

PDB ID 3dv2

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