1xx0

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{{Seed}}
 
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[[Image:1xx0.png|left|200px]]
 
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==Structure of the C-terminal PH domain of human pleckstrin==
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The line below this paragraph, containing "STRUCTURE_1xx0", creates the "Structure Box" on the page.
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<StructureSection load='1xx0' size='340' side='right'caption='[[1xx0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XX0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xx0 OCA], [https://pdbe.org/1xx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xx0 RCSB], [https://www.ebi.ac.uk/pdbsum/1xx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xx0 ProSAT]</span></td></tr>
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{{STRUCTURE_1xx0| PDB=1xx0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLEK_HUMAN PLEK_HUMAN] Major protein kinase C substrate of platelets.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xx0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xx0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pleckstrin is the major target of protein kinase C (PKC) in blood platelets. Its phosphorylation triggers responses that ultimately lead to platelet activation and blood clot formation. Pleckstrin consists of three domains: a pleckstrin homology (PH) domain at both termini and a central DEP (Dishevelled, Egl-1, Pleckstrin) domain. Here, we report the solution nuclear magnetic resonance (NMR) structure of the C-terminal PH domain (C-PH) of human pleckstrin-1. We show that this PH domain binds phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4)P2) with high specificity in protein lipid overlay assays. Using NMR titration experiments and mutational analysis, residues involved in binding to PtdIns(3,4)P2 are identified. The binding site is formed by a patch of basic residues from the beta1 and beta2 strands and the beta1-beta2 loop. Since PtdIns(3,4)P2 is an important signaling molecule in platelets, our data suggest a C-PH dependent regulation of pleckstrin function in response to PtdIns(3,4)P2.
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===Structure of the C-terminal PH domain of human pleckstrin===
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Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin.,Edlich C, Stier G, Simon B, Sattler M, Muhle-Goll C Structure. 2005 Feb;13(2):277-86. PMID:15698571<ref>PMID:15698571</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15698571}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1xx0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15698571 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15698571}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1XX0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XX0 OCA].
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==Reference==
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<ref group="xtra">PMID:15698571</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Edlich, C.]]
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[[Category: Large Structures]]
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[[Category: Muhle-Goll, C.]]
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[[Category: Edlich C]]
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[[Category: Sattler, M.]]
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[[Category: Muhle-Goll C]]
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[[Category: Simon, B.]]
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[[Category: Sattler M]]
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[[Category: Stier, G.]]
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[[Category: Simon B]]
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[[Category: C-terminal]]
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[[Category: Stier G]]
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[[Category: Ph]]
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[[Category: Pleckstrin]]
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[[Category: Pleckstrin homology]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:26:50 2009''
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Current revision

Structure of the C-terminal PH domain of human pleckstrin

PDB ID 1xx0

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