2q3h

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{{Seed}}
 
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[[Image:2q3h.png|left|200px]]
 
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==The crystal structure of RhouA in the GDP-bound state.==
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The line below this paragraph, containing "STRUCTURE_2q3h", creates the "Structure Box" on the page.
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<StructureSection load='2q3h' size='340' side='right'caption='[[2q3h]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2q3h| PDB=2q3h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3h OCA], [https://pdbe.org/2q3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3h RCSB], [https://www.ebi.ac.uk/pdbsum/2q3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3h ProSAT]</span></td></tr>
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</table>
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===The crystal structure of RhouA in the GDP-bound state.===
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== Function ==
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[https://www.uniprot.org/uniprot/RHOU_HUMAN RHOU_HUMAN] Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.<ref>PMID:11459829</ref> <ref>PMID:16472646</ref> <ref>PMID:17620058</ref> <ref>PMID:18086875</ref> <ref>PMID:21834987</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2Q3H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3H OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3h ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bray, J.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bray J]]
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[[Category: Delft, F von.]]
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[[Category: Bunkoczi G]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins J]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov O]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou E]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Umeano C]]
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[[Category: Umeano, C.]]
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[[Category: Uppenberg J]]
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[[Category: Uppenberg, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yang X]]
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[[Category: Yang, X.]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y.]]
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[[Category: Von Delft F]]
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[[Category: Gtpase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:29:00 2009''
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Current revision

The crystal structure of RhouA in the GDP-bound state.

PDB ID 2q3h

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