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1zow

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{{Seed}}
 
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[[Image:1zow.png|left|200px]]
 
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==Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase III==
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The line below this paragraph, containing "STRUCTURE_1zow", creates the "Structure Box" on the page.
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<StructureSection load='1zow' size='340' side='right'caption='[[1zow]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zow]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZOW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zow OCA], [https://pdbe.org/1zow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zow RCSB], [https://www.ebi.ac.uk/pdbsum/1zow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zow ProSAT]</span></td></tr>
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{{STRUCTURE_1zow| PDB=1zow | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABH_STAAW FABH_STAAW] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zo/1zow_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zow ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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beta-Ketoacyl-ACP synthase III (FabH), an essential enzyme for bacterial viability, catalyzes the initiation of fatty acid elongation by condensing malonyl-ACP with acetyl-CoA. We have determined the crystal structure of FabH from Staphylococcus aureus, a Gram-positive human pathogen, to 2 A resolution. Although the overall structure of S. aureus FabH is similar to that of Escherichia coli FabH, the primer binding pocket in S. aureus FabH is significantly larger than that present in E. coli FabH. The structural differences, which agree with kinetic parameters, provide explanation for the observed varying substrate specificity for E. coli and S. aureus FabH. The rank order of activity of S. aureus FabH with various acyl-CoA primers was as follows: isobutyryl- &gt; hexanoyl- &gt; butyryl- &gt; isovaleryl- &gt;&gt; acetyl-CoA. The availability of crystal structure may aid in designing potent, selective inhibitors of S. aureus FabH.
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===Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase III===
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Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus.,Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS Protein Sci. 2005 Aug;14(8):2087-94. Epub 2005 Jun 29. PMID:15987898<ref>PMID:15987898</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1zow" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15987898}}, adds the Publication Abstract to the page
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15987898 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_15987898}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZOW is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOW OCA].
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[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Choudhry AE]]
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==Reference==
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[[Category: Daines RA]]
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<ref group="xtra">PMID:15987898</ref><references group="xtra"/>
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[[Category: Grooms M]]
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[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
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[[Category: Janson CA]]
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[[Category: Staphylococcus aureus]]
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[[Category: Khandekar SS]]
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[[Category: Choudhry, A E.]]
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[[Category: Lonsdale JT]]
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[[Category: Daines, R A.]]
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[[Category: Qiu X]]
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[[Category: Grooms, M.]]
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[[Category: Janson, C A.]]
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[[Category: Khandekar, S S.]]
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[[Category: Lonsdale, J T.]]
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[[Category: Qiu, X.]]
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[[Category: Fabh]]
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[[Category: Fatty acid biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:31:29 2009''
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Current revision

Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase III

PDB ID 1zow

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