1brt

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{{Seed}}
 
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[[Image:1brt.png|left|200px]]
 
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==BROMOPEROXIDASE A2 MUTANT M99T==
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The line below this paragraph, containing "STRUCTURE_1brt", creates the "Structure Box" on the page.
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<StructureSection load='1brt' size='340' side='right'caption='[[1brt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1brt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kitasatospora_aureofaciens Kitasatospora aureofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BRT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1brt| PDB=1brt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1brt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1brt OCA], [https://pdbe.org/1brt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1brt RCSB], [https://www.ebi.ac.uk/pdbsum/1brt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1brt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPOA2_KITAU BPOA2_KITAU] May be a chlorinating enzyme involved in 7-chlorotetracycline biosynthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/1brt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1brt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of cofactor-free haloperoxidases from Streptomyces aureofaciens, Streptomyces lividans, and Pseudomonas fluorescens have been determined at resolutions between 1.9 A and 1.5 A. The structures of two enzymes complexed with benzoate or propionate identify the binding site for the organic acids which are required for the haloperoxidase activity. Based on these complexes and on the structure of an inactive variant, a reaction mechanism is proposed for the halogenation reaction with peroxoacid and hypohalous acid as reaction intermediates. Comparison of the structures suggests that a specific halide binding site is absent in the enzymes but that hydrophobic organic compounds may fit into the active site pocket for halogenation at preferential sites.
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===BROMOPEROXIDASE A2 MUTANT M99T===
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Structural investigation of the cofactor-free chloroperoxidases.,Hofmann B, Tolzer S, Pelletier I, Altenbuchner J, van Pee KH, Hecht HJ J Mol Biol. 1998 Jun 19;279(4):889-900. PMID:9642069<ref>PMID:9642069</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1brt" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9642069}}, adds the Publication Abstract to the page
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*[[Haloperoxidase|Haloperoxidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9642069 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9642069}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Kitasatospora aureofaciens]]
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1BRT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_aureofaciens Streptomyces aureofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BRT OCA].
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[[Category: Large Structures]]
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[[Category: Altenbuchner J]]
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==Reference==
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[[Category: Hecht HJ]]
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<ref group="xtra">PMID:9642069</ref><references group="xtra"/>
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[[Category: Hofmann B]]
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[[Category: Chloride peroxidase]]
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[[Category: Pelletier I]]
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[[Category: Streptomyces aureofaciens]]
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[[Category: Toelzer S]]
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[[Category: Altenbuchner, J.]]
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[[Category: Van Pee KH]]
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[[Category: Hecht, H J.]]
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[[Category: Hofmann, B.]]
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[[Category: Pee, K H.Van.]]
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[[Category: Pelletier, I.]]
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[[Category: Toelzer, S.]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Haloperoxidase]]
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[[Category: Mutant m99t]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:45:19 2009''
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Current revision

BROMOPEROXIDASE A2 MUTANT M99T

PDB ID 1brt

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