1o95

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{{Seed}}
 
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[[Image:1o95.png|left|200px]]
 
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==Ternary complex between trimethylamine dehydrogenase and electron transferring flavoprotein==
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The line below this paragraph, containing "STRUCTURE_1o95", creates the "Structure Box" on the page.
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<StructureSection load='1o95' size='340' side='right'caption='[[1o95]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o95]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O95 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1o95| PDB=1o95 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o95 OCA], [https://pdbe.org/1o95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o95 RCSB], [https://www.ebi.ac.uk/pdbsum/1o95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o95 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHTM_METME DHTM_METME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/1o95_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o95 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we report the crystal structures of a ternary electron transfer complex showing extensive motion at the protein interface. This physiological complex comprises the iron-sulfur flavoprotein trimethylamine dehydrogenase and electron transferring flavoprotein (ETF) from Methylophilus methylotrophus. In addition, we report the crystal structure of free ETF. In the complex, electron density for the FAD domain of ETF is absent, indicating high mobility. Positions for the FAD domain are revealed by molecular dynamics simulation, consistent with crystal structures and kinetic data. A dual interaction of ETF with trimethylamine dehydrogenase provides for dynamical motion at the protein interface: one site acts as an anchor, thereby allowing the other site to sample a large range of interactions, some compatible with rapid electron transfer. This study establishes the role of conformational sampling in multi-domain redox systems, providing insight into electron transfer between ETFs and structurally distinct redox partners.
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===TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN===
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Extensive conformational sampling in a ternary electron transfer complex.,Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183<ref>PMID:12567183</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12567183}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1o95" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12567183 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12567183}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1O95 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O95 OCA].
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==Reference==
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<ref group="xtra">PMID:12567183</ref><references group="xtra"/>
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[[Category: Methylophilus methylotrophus]]
[[Category: Methylophilus methylotrophus]]
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[[Category: Trimethylamine dehydrogenase]]
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[[Category: Basran J]]
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[[Category: Basran, J.]]
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[[Category: Leys D]]
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[[Category: Leys, D.]]
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[[Category: Scrutton NS]]
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[[Category: Scrutton, N S.]]
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[[Category: Sutcliffe MJ]]
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[[Category: Sutcliffe, M J.]]
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[[Category: Talfournier F]]
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[[Category: Talfournier, F.]]
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[[Category: Dehydrogenase,electron transport,flavoprotein,oxido-reductase,iron-sulfur,fmn]]
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[[Category: Electron transfer]]
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[[Category: Protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:46:28 2009''
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Current revision

Ternary complex between trimethylamine dehydrogenase and electron transferring flavoprotein

PDB ID 1o95

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