This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jsg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:41, 7 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1jsg.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY==
-
The line below this paragraph, containing "STRUCTURE_1jsg", creates the "Structure Box" on the page.
+
<StructureSection load='1jsg' size='340' side='right'caption='[[1jsg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1jsg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSG FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsg OCA], [https://pdbe.org/1jsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsg RCSB], [https://www.ebi.ac.uk/pdbsum/1jsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsg ProSAT]</span></td></tr>
-
{{STRUCTURE_1jsg| PDB=1jsg | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY===
+
[https://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN] Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/TCL1A_HUMAN TCL1A_HUMAN] Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.<ref>PMID:10983986</ref> <ref>PMID:10716693</ref> <ref>PMID:11707444</ref> <ref>PMID:11839817</ref>
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_9519406}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9519406 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_9519406}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsg_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
1JSG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSG OCA].
+
</jmolCheckbox>
-
 
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsg ConSurf].
-
==Reference==
+
<div style="clear:both"></div>
-
<ref group="xtra">PMID:9519406</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Guignard, L.]]
+
[[Category: Large Structures]]
-
[[Category: Hoh, F.]]
+
[[Category: Guignard L]]
-
[[Category: Lhoste, J M.]]
+
[[Category: Hoh F]]
-
[[Category: Padilla, A.]]
+
[[Category: Lhoste J-M]]
-
[[Category: Stern, R H.]]
+
[[Category: Padilla A]]
-
[[Category: Tilbeurgh, H Van.]]
+
[[Category: Stern R-H]]
-
[[Category: Yang, Y S.]]
+
[[Category: Van Tilbeurgh H]]
-
[[Category: Cl1 gene]]
+
[[Category: Yang Y-S]]
-
[[Category: Microsome]]
+
-
[[Category: Oncoprotein]]
+
-
[[Category: Proto-oncogene]]
+
-
[[Category: T cell leukemia]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:49:06 2009''
+

Current revision

CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCT INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA, REVEALS A NOVEL B-BARREL TOPOLOGY

PDB ID 1jsg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jsg"
Personal tools