2cyx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:21, 25 October 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2cyx.png|left|200px]]
 
-
<!--
+
==Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)==
-
The line below this paragraph, containing "STRUCTURE_2cyx", creates the "Structure Box" on the page.
+
<StructureSection load='2cyx' size='340' side='right'caption='[[2cyx]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2cyx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYX FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyx OCA], [https://pdbe.org/2cyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyx RCSB], [https://www.ebi.ac.uk/pdbsum/2cyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyx ProSAT], [https://www.topsan.org/Proteins/RSGI/2cyx TOPSAN]</span></td></tr>
-
{{STRUCTURE_2cyx| PDB=2cyx | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UB2G2_HUMAN UB2G2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).<ref>PMID:20061386</ref> <ref>PMID:22607976</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyx_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cyx ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in protein degradation, including a process known as endoplasmic reticulum-associated degradation (ERAD). The crystal structure of human UBE2G2/UBC7 was solved at 2.56 angstroms resolution. The UBE2G2 structure comprises a single domain consisting of an antiparallel beta-sheet with four strands, five alpha-helices and two 3(10)-helices. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. Superimposition of UBE2G2 on UbcH7 in a c-Cbl-UbcH7-ZAP70 ternary complex suggested that the two loop regions of UBE2G2 interact with the RING domain in a similar way to UbcH7. In addition, the extra loop region of UBE2G2 may interact with the RING domain or its neighbouring region and may be involved in the binding specificity and stability.
-
===Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)===
+
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7).,Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478<ref>PMID:16582478</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2cyx" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16582478}}, adds the Publication Abstract to the page
+
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16582478 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_16582478}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2CYX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYX OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16582478</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ubiquitin--protein ligase]]
+
[[Category: Large Structures]]
-
[[Category: Arai, R.]]
+
[[Category: Arai R]]
-
[[Category: Imai, Y.]]
+
[[Category: Imai Y]]
-
[[Category: Murayama, K.]]
+
[[Category: Murayama K]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Shirouzu M]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Takahashi R]]
-
[[Category: Takahashi, R.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yoshikawa S]]
-
[[Category: Yoshikawa, S.]]
+
-
[[Category: Ligase]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Ubl conjugation pathway]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:52:47 2009''
+

Current revision

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)

PDB ID 2cyx

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cyx"
Personal tools