3duz

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{{Seed}}
 
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[[Image:3duz.png|left|200px]]
 
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==Crystal structure of the postfusion form of baculovirus fusion protein GP64==
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The line below this paragraph, containing "STRUCTURE_3duz", creates the "Structure Box" on the page.
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<StructureSection load='3duz' size='340' side='right'caption='[[3duz]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3duz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DUZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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{{STRUCTURE_3duz| PDB=3duz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3duz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3duz OCA], [https://pdbe.org/3duz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3duz RCSB], [https://www.ebi.ac.uk/pdbsum/3duz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3duz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FUS_NPVAC FUS_NPVAC] Envelope phosphoglycoprotein which mediates the fusion of viral and host endosomal membranes leading to virus entry into the host cell.<ref>PMID:20739531</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/3duz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3duz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Viral fusion proteins mediate the merger of host and viral membranes during cell entry for all enveloped viruses. Baculovirus glycoprotein gp64 (gp64) is unusual in promoting entry into both insect and mammalian cells and is distinct from established class I and class II fusion proteins. We report the crystal structure of its postfusion form, which explains a number of gp64's biological properties including its cellular promiscuity, identifies the fusion peptides and shows it to be the third representative of a new class (III) of fusion proteins with unexpected structural homology with vesicular stomatitis virus G and herpes simplex virus type 1 gB proteins. We show that domains of class III proteins have counterparts in both class I and II proteins, suggesting that all these viral fusion machines are structurally more related than previously thought.
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===Crystal structure of the postfusion form of baculovirus fusion protein GP64===
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The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines.,Kadlec J, Loureiro S, Abrescia NG, Stuart DI, Jones IM Nat Struct Mol Biol. 2008 Oct;15(10):1024-30. Epub 2008 Sep 7. PMID:18776902<ref>PMID:18776902</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18776902}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3duz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18776902 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18776902}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3DUZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DUZ OCA].
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==Reference==
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<ref group="xtra">PMID:18776902</ref><references group="xtra"/>
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[[Category: Autographa californica nucleopolyhedrovirus]]
[[Category: Autographa californica nucleopolyhedrovirus]]
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[[Category: Abrescia, N G.A.]]
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[[Category: Large Structures]]
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[[Category: Jones, I M.]]
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[[Category: Abrescia NGA]]
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[[Category: Kadlec, J.]]
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[[Category: Jones IM]]
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[[Category: Loureiro, S.]]
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[[Category: Kadlec J]]
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[[Category: Stuart, D I.]]
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[[Category: Loureiro S]]
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[[Category: Coiled-coil]]
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[[Category: Stuart DI]]
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[[Category: Fusion peptide]]
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[[Category: Fusion protein]]
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[[Category: Glycoprotein]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Transmembrane]]
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[[Category: Trimer]]
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[[Category: Viral]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:56:58 2009''
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Current revision

Crystal structure of the postfusion form of baculovirus fusion protein GP64

PDB ID 3duz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3duz"
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