1tzo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:43, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1tzo.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore==
-
The line below this paragraph, containing "STRUCTURE_1tzo", creates the "Structure Box" on the page.
+
<StructureSection load='1tzo' size='340' side='right'caption='[[1tzo]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1tzo]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._A2012 Bacillus anthracis str. A2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TZO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_1tzo| PDB=1tzo | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzo OCA], [https://pdbe.org/1tzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tzo RCSB], [https://www.ebi.ac.uk/pdbsum/1tzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tzo ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_15326297}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15326297 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tz/1tzo_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_15326297}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1TZO is a 14 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZO OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tzo ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:15326297</ref><references group="xtra"/>
+
</StructureSection>
-
[[Category: Bacillus anthracis]]
+
[[Category: Bacillus anthracis str. A2012]]
-
[[Category: Collier, R J.]]
+
[[Category: Large Structures]]
-
[[Category: Lacy, D B.]]
+
[[Category: Collier RJ]]
-
[[Category: Melnyk, R A.]]
+
[[Category: Lacy DB]]
-
[[Category: Wigelsworth, D J.]]
+
[[Category: Melnyk RA]]
-
[[Category: Heptamer]]
+
[[Category: Wigelsworth DJ]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:03:36 2009''
+

Current revision

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore

PDB ID 1tzo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tzo"
Personal tools