1nub

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{{Seed}}
 
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[[Image:1nub.png|left|200px]]
 
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<!--
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==HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR==
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The line below this paragraph, containing "STRUCTURE_1nub", creates the "Structure Box" on the page.
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<StructureSection load='1nub' size='340' side='right'caption='[[1nub]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NUB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1nub| PDB=1nub | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nub OCA], [https://pdbe.org/1nub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nub RCSB], [https://www.ebi.ac.uk/pdbsum/1nub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nub ProSAT]</span></td></tr>
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</table>
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===HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR===
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== Function ==
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[https://www.uniprot.org/uniprot/SPRC_HUMAN SPRC_HUMAN] Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9501084}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9501084 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nu/1nub_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9501084}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1NUB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NUB OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nub ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:9501084</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hohenester, E.]]
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[[Category: Large Structures]]
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[[Category: Sasaki, T.]]
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[[Category: Hohenester E]]
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[[Category: Timpl, R.]]
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[[Category: Sasaki T]]
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[[Category: Anti-adhesive protein]]
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[[Category: Timpl R]]
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[[Category: Collagen binding]]
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[[Category: Extracellular module]]
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[[Category: Glycoprotein]]
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[[Category: Glycosylated protein]]
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[[Category: Site-directed mutagenesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:21:06 2009''
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Current revision

HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR

PDB ID 1nub

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