2e44

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(New page: 200px<br /><applet load="2e44" size="450" color="white" frame="true" align="right" spinBox="true" caption="2e44" /> '''Solution structure of RNA binding domain in ...)
Current revision (18:46, 29 May 2024) (edit) (undo)
 
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[[Image:2e44.jpg|left|200px]]<br /><applet load="2e44" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2e44" />
 
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'''Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3'''<br />
 
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==About this Structure==
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==Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3==
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2E44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2E44 OCA].
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<StructureSection load='2e44' size='340' side='right'caption='[[2e44]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2e44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E44 FirstGlance]. <br>
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[[Category: Furue, M.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e44 OCA], [https://pdbe.org/2e44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e44 RCSB], [https://www.ebi.ac.uk/pdbsum/2e44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e44 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e44 TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Muto, Y.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/IF2B3_HUMAN IF2B3_HUMAN] RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<ref>PMID:16541107</ref> <ref>PMID:23640942</ref>
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[[Category: Shirouzu, M.]]
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== Evolutionary Conservation ==
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[[Category: Terada, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Tsuda, K.]]
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Check<jmol>
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[[Category: Yokoyama, S.]]
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<jmolCheckbox>
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[[Category: national project on protein structural and functional analyses]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e4/2e44_consurf.spt"</scriptWhenChecked>
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[[Category: nppsfa]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: rbd]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: riken structural genomics/proteomics initiative]]
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</jmolCheckbox>
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[[Category: rrm domain]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e44 ConSurf].
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[[Category: rsgi]]
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<div style="clear:both"></div>
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:56:17 2007''
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==See Also==
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*[[Insulin-like growth factor 2 mRNA-binding protein|Insulin-like growth factor 2 mRNA-binding protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Furue M]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Muto Y]]
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[[Category: Shirouzu M]]
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[[Category: Terada T]]
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[[Category: Tsuda K]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3

PDB ID 2e44

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