2v5p

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{{Seed}}
 
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[[Image:2v5p.png|left|200px]]
 
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==COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II==
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The line below this paragraph, containing "STRUCTURE_2v5p", creates the "Structure Box" on the page.
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<StructureSection load='2v5p' size='340' side='right'caption='[[2v5p]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2v5p| PDB=2v5p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5p OCA], [https://pdbe.org/2v5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5p RCSB], [https://www.ebi.ac.uk/pdbsum/2v5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.
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===COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II===
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Structure and functional analysis of the IGF-II/IGF2R interaction.,Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459<ref>PMID:18046459</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2v5p" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18046459}}, adds the Publication Abstract to the page
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*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18046459 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18046459}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2V5P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5P OCA].
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==Reference==
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<ref group="xtra">PMID:18046459</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boxel, G Van.]]
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[[Category: Large Structures]]
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[[Category: Brown, J.]]
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[[Category: Brown J]]
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[[Category: Delaine, C.]]
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[[Category: Delaine C]]
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[[Category: Denley, A.]]
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[[Category: Denley A]]
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[[Category: Forbes, B E.]]
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[[Category: Forbes BE]]
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[[Category: Gilbert, R J.]]
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[[Category: Gilbert RJ]]
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[[Category: Hassan, A B.]]
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[[Category: Hassan AB]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Siebold, C.]]
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[[Category: Siebold C]]
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[[Category: Wallace, J C.]]
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[[Category: Wallace JC]]
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[[Category: Zaccheo, O J.]]
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[[Category: Zaccheo OJ]]
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[[Category: Beta barrel]]
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[[Category: Van Boxel G]]
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[[Category: Cation independent mannose 6-phosphate]]
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[[Category: Fibronectin type ii]]
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[[Category: Glycoprotein]]
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[[Category: Insulin-like growth factor]]
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[[Category: Lysosome]]
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[[Category: Membrane]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Receptor/glycoprotein complex]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:35:25 2009''
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Current revision

COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II

PDB ID 2v5p

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