2r42

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{{Seed}}
 
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[[Image:2r42.png|left|200px]]
 
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==The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism==
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The line below this paragraph, containing "STRUCTURE_2r42", creates the "Structure Box" on the page.
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<StructureSection load='2r42' size='340' side='right'caption='[[2r42]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R42 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2r42| PDB=2r42 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r42 OCA], [https://pdbe.org/2r42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r42 RCSB], [https://www.ebi.ac.uk/pdbsum/2r42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r42 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
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== Function ==
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[https://www.uniprot.org/uniprot/KIME_RAT KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r42_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r42 ConSurf].
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<div style="clear:both"></div>
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===The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism===
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==See Also==
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*[[Mevalonate kinase|Mevalonate kinase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18302342}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18302342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18302342}}
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==About this Structure==
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2R42 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R42 OCA].
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==Reference==
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<ref group="xtra">PMID:18302342</ref><references group="xtra"/>
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[[Category: Mevalonate kinase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Fu, Z.]]
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[[Category: Fu Z]]
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[[Category: Kim, J P.]]
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[[Category: Kim JP]]
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[[Category: Miziorko, H M.]]
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[[Category: Miziorko HM]]
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[[Category: Voynova, N E.]]
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[[Category: Voynova NE]]
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[[Category: Atp-binding]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Cytoplasm]]
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[[Category: Farnesyl thiodiphosphate]]
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[[Category: Lipid synthesis]]
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[[Category: Mevalonate kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Peroxisome]]
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[[Category: Steroid biosynthesis]]
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[[Category: Sterol biosynthesis]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:52:15 2009''
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Current revision

The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism

PDB ID 2r42

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