1ybi

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{{Seed}}
 
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[[Image:1ybi.png|left|200px]]
 
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==Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A==
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The line below this paragraph, containing "STRUCTURE_1ybi", creates the "Structure Box" on the page.
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<StructureSection load='1ybi' size='340' side='right'caption='[[1ybi]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ybi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YBI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ybi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ybi OCA], [https://pdbe.org/1ybi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ybi RCSB], [https://www.ebi.ac.uk/pdbsum/1ybi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ybi ProSAT]</span></td></tr>
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{{STRUCTURE_1ybi| PDB=1ybi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q45871_CLOBO Q45871_CLOBO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1ybi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ybi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold.
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===Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A===
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The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex.,Arndt JW, Gu J, Jaroszewski L, Schwarzenbacher R, Hanson MA, Lebeda FJ, Stevens RC J Mol Biol. 2005 Mar 4;346(4):1083-93. Epub 2005 Jan 20. PMID:15701519<ref>PMID:15701519</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15701519}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ybi" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15701519 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15701519}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1YBI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YBI OCA].
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==Reference==
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<ref group="xtra">PMID:15701519</ref><references group="xtra"/>
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Arndt, J W.]]
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[[Category: Large Structures]]
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[[Category: Gu, J.]]
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[[Category: Arndt JW]]
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[[Category: Hanson, M.]]
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[[Category: Gu J]]
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[[Category: Jaroszewski, L.]]
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[[Category: Hanson M]]
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[[Category: Lebeda, F J.]]
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[[Category: Jaroszewski L]]
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[[Category: Schwarzenbacher, R.]]
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[[Category: Lebeda FJ]]
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[[Category: Stevens, R C.]]
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[[Category: Schwarzenbacher R]]
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[[Category: Beta-trefoil]]
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[[Category: Stevens RC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:54:49 2009''
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Current revision

Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A

PDB ID 1ybi

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