1d7i

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{{Seed}}
 
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[[Image:1d7i.png|left|200px]]
 
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==FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)==
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The line below this paragraph, containing "STRUCTURE_1d7i", creates the "Structure Box" on the page.
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<StructureSection load='1d7i' size='340' side='right'caption='[[1d7i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D7I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSS:METHYL+METHYLSULFINYLMETHYL+SULFIDE'>DSS</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1d7i| PDB=1d7i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d7i OCA], [https://pdbe.org/1d7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d7i RCSB], [https://www.ebi.ac.uk/pdbsum/1d7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d7i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d7/1d7i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d7i ConSurf].
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<div style="clear:both"></div>
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===FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10656803 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10656803}}
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==About this Structure==
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1D7I is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7I OCA].
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==Reference==
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<ref group="xtra">PMID:10656803</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Burkhard, P.]]
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[[Category: Burkhard P]]
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[[Category: Taylor, P.]]
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[[Category: Taylor P]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Walkinshaw MD]]
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[[Category: Dss]]
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[[Category: Fkbp]]
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[[Category: Immunophilin]]
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[[Category: Isomerase]]
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[[Category: Methyl methylsulfinylmethyl sulfide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:56:03 2009''
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Current revision

FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)

PDB ID 1d7i

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