1vgm

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{{Seed}}
 
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[[Image:1vgm.png|left|200px]]
 
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==Crystal Structure of an Isozyme of Citrate Synthase from Sulfolbus tokodaii strain7==
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The line below this paragraph, containing "STRUCTURE_1vgm", creates the "Structure Box" on the page.
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<StructureSection load='1vgm' size='340' side='right'caption='[[1vgm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VGM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1vgm| PDB=1vgm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vgm OCA], [https://pdbe.org/1vgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vgm RCSB], [https://www.ebi.ac.uk/pdbsum/1vgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vgm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q96ZM7_SULTO Q96ZM7_SULTO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vg/1vgm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vgm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thermoacidophilic archaeon Sulfolobus tokodaii strain 7 has two citrate synthase genes (ST1805-CS and ST0587-CS) in the genome with 45% sequence identity. Because they exhibit similar optimal temperatures of catalytic activity and thermal inactivation profiles, we performed structural comparisons between these isozymes to elucidate adaptation mechanisms to high temperatures in thermophilic CSs. The crystal structures of ST1805-CS and ST0587-CS were determined at 2.0 A and 2.7 A resolutions, respectively. Structural comparison reveals that both of them are dimeric enzymes composed of two identical subunits, and these dimeric structures are quite similar to those of citrate synthases from archaea and eubacteria. ST0587-CS has, however, 55 ion pairs within whole dimer structure, while having only 36 in ST1805-CS. Although the number and distributions of ion pairs are distinct from each other, intersubunit ion pairs between two domains of each isozyme are identical especially in interterminal region. Because the location and number of ion pairs are in a trend with other CSs from thermophilic microorganisms, the factors responsible for thermal adaptation of ST-CS isozymes are characterized by ion pairs in interterminal region.
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===Crystal Structure of an Isozyme of Citrate Synthase from Sulfolbus tokodaii strain7===
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Crystal Structures of Two Isozymes of Citrate Synthase from Sulfolobus tokodaii Strain 7.,Murakami M, Kouyama T Biochem Res Int. 2016;2016:7560919. doi: 10.1155/2016/7560919. Epub 2016 Aug 30. PMID:27656296<ref>PMID:27656296</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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1VGM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGM OCA].
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<div class="pdbe-citations 1vgm" style="background-color:#fffaf0;"></div>
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[[Category: Sulfolobus tokodaii]]
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== References ==
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[[Category: Ihara, K.]]
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<references/>
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[[Category: Kouyama, T.]]
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__TOC__
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[[Category: Murakami, M.]]
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</StructureSection>
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[[Category: Open form]]
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[[Category: Large Structures]]
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[[Category: Sulfurisphaera tokodaii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:59:04 2009''
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[[Category: Ihara K]]
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[[Category: Kouyama T]]
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[[Category: Murakami M]]

Current revision

Crystal Structure of an Isozyme of Citrate Synthase from Sulfolbus tokodaii strain7

PDB ID 1vgm

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