2jnb

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{{Seed}}
 
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[[Image:2jnb.png|left|200px]]
 
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==Solution Structure of RNA-binding protein 15.5K==
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The line below this paragraph, containing "STRUCTURE_2jnb", creates the "Structure Box" on the page.
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<StructureSection load='2jnb' size='340' side='right'caption='[[2jnb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnb OCA], [https://pdbe.org/2jnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnb RCSB], [https://www.ebi.ac.uk/pdbsum/2jnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnb ProSAT]</span></td></tr>
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{{STRUCTURE_2jnb| PDB=2jnb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NH2L1_HUMAN NH2L1_HUMAN] Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.<ref>PMID:10545122</ref> <ref>PMID:17412961</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/2jnb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jnb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The kink-turn (K-turn) motif is recognized and bound by a family of proteins that act as nucleation factors for ribonucleoparticle assembly. The binding of various proteins to a conserved RNA structural motif known as the K-turn has been shown to be an important component of regulation in the ribosome, in the spliceosome, and in RNA modification. 15.5K is a prototypical example of a K-turn binding protein, which has been shown to bind the 5'-U4 stem-loop of the spliceosome and the box C/D motif. We describe the solution NMR structure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H/D exchange experiments. The protein appears well-structured aside from conformational fluctuation in alpha3. Flexibility in fast time scale motions and the observation of limited intermediate and slow motions further characterize the free protein and may suggest local contributions to recognition and binding.
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===Solution Structure of RNA-binding protein 15.5K===
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Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K.,Soss SE, Flynn PF Biochemistry. 2007 Dec 25;46(51):14979-86. Epub 2007 Nov 29. PMID:18044964<ref>PMID:18044964</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18044964}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jnb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18044964 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18044964}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2JNB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNB OCA].
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==Reference==
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<ref group="xtra">PMID:18044964</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Flynn, P F.]]
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[[Category: Large Structures]]
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[[Category: Soss, S E.]]
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[[Category: Flynn PF]]
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[[Category: Kink-turn rna-binding protein]]
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[[Category: Soss SE]]
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[[Category: Nhpx]]
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[[Category: Rna binding protein]]
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[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:59:29 2009''
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Current revision

Solution Structure of RNA-binding protein 15.5K

PDB ID 2jnb

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OCA

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