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1knz

From Proteopedia

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{{Seed}}
 
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[[Image:1knz.png|left|200px]]
 
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==Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer==
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The line below this paragraph, containing "STRUCTURE_1knz", creates the "Structure Box" on the page.
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<StructureSection load='1knz' size='340' side='right'caption='[[1knz]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1knz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus_A/SA11 Simian rotavirus A/SA11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KNZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1knz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1knz OCA], [https://pdbe.org/1knz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1knz RCSB], [https://www.ebi.ac.uk/pdbsum/1knz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1knz ProSAT]</span></td></tr>
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{{STRUCTURE_1knz| PDB=1knz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NSP3_ROTS1 NSP3_ROTS1] Involved in the shutoff of host protein synthesis. It is unclear whether it is required for the translation of viral mRNAs as well. Functions similarly to, and competes with the cellular poly(A)-binding protein PABPC1. Binds the conserved sequence 'GACC' at the 3' end of viral mRNAs and allows circularization of viral mRNAs in translation. Interacts with ZC3H7B/RoXaN and with the eukaryotic translation initiation factor eIF4G, using the same region employed by PABP-C1. NSP3 thus displaces PABPC1 from eIF4G, inhibiting the translation of cellular poly(A) mRNAs. Also responsible for the nuclear relocalization of PABPC1 upon rotavirus infection (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/1knz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1knz ConSurf].
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<div style="clear:both"></div>
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===Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer===
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==See Also==
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11792322}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11792322 is the PubMed ID number.
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[[Category: Simian rotavirus A/SA11]]
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[[Category: Burley SK]]
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{{ABSTRACT_PUBMED_11792322}}
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[[Category: Deo RC]]
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[[Category: Groft CM]]
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==About this Structure==
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[[Category: Rajashankar KR]]
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1KNZ is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Simian_rotavirus_a/sa11 Simian rotavirus a/sa11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KNZ OCA].
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==Reference==
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<ref group="xtra">PMID:11792322</ref><references group="xtra"/>
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[[Category: Simian rotavirus a/sa11]]
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[[Category: Burley, S K.]]
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[[Category: Deo, R C.]]
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[[Category: Groft, C M.]]
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[[Category: Rajashankar, K R.]]
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[[Category: Protein-ssrna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:00:18 2009''
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Current revision

Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer

PDB ID 1knz

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