1rqu

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{{Seed}}
 
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[[Image:1rqu.png|left|200px]]
 
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==NMR structure of L7 dimer from E.coli==
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The line below this paragraph, containing "STRUCTURE_1rqu", creates the "Structure Box" on the page.
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<StructureSection load='1rqu' size='340' side='right'caption='[[1rqu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RQU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqu OCA], [https://pdbe.org/1rqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rqu RCSB], [https://www.ebi.ac.uk/pdbsum/1rqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqu ProSAT]</span></td></tr>
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{{STRUCTURE_1rqu| PDB=1rqu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL7_ECOLI RL7_ECOLI] Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation.[HAMAP-Rule:MF_00368]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rqu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Based on the (1)H-(15)N NMR spectroscopy data, the three-dimensional structure and internal dynamic properties of ribosomal protein L7 from Escherichia coli were derived. The structure of L7 dimer in solution can be described as a set of three distinct domains, tumbling rather independently and linked via flexible hinge regions. The dimeric N-terminal domain (residues 1-32) consists of two antiparallel alpha-alpha-hairpins forming a symmetrical four-helical bundle, whereas the two identical C-terminal domains (residues 52-120) adopt a compact alpha/beta-fold. There is an indirect evidence of the existence of transitory helical structures at least in the first part (residues 33-43) of the hinge region. Combining structural data for the ribosomal protein L7/L12 from NMR spectroscopy and x-ray crystallography, it was suggested that its hinge region acts as a molecular switch, initiating "ratchet-like" motions of the L7/L12 stalk with respect to the ribosomal surface in response to elongation factor binding and GTP hydrolysis. This hypothesis allows an explanation of events observed during the translation cycle and provides useful insights into the role of protein L7/L12 in the functioning of the ribosome.
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===NMR structure of L7 dimer from E.coli===
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From structure and dynamics of protein L7/L12 to molecular switching in ribosome.,Bocharov EV, Sobol AG, Pavlov KV, Korzhnev DM, Jaravine VA, Gudkov AT, Arseniev AS J Biol Chem. 2004 Apr 23;279(17):17697-706. Epub 2004 Feb 11. PMID:14960595<ref>PMID:14960595</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1rqu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14960595}}, adds the Publication Abstract to the page
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*[[Ribosomal protein L7/L12|Ribosomal protein L7/L12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14960595 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14960595}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1RQU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQU OCA].
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==Reference==
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<ref group="xtra">PMID:14960595</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Arseniev, A S.]]
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[[Category: Large Structures]]
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[[Category: Bocharov, E V.]]
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[[Category: Arseniev AS]]
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[[Category: Gudkov, A T.]]
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[[Category: Bocharov EV]]
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[[Category: Jaravine, V A.]]
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[[Category: Gudkov AT]]
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[[Category: Korzhnev, D M.]]
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[[Category: Jaravine VA]]
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[[Category: Pavlov, K V.]]
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[[Category: Korzhnev DM]]
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[[Category: Sobol, A G.]]
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[[Category: Pavlov KV]]
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[[Category: Nmr]]
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[[Category: Sobol AG]]
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[[Category: Protein l7/l12]]
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[[Category: Ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:21:30 2009''
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Current revision

NMR structure of L7 dimer from E.coli

PDB ID 1rqu

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