1j0t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:40, 27 December 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1j0t.png|left|200px]]
 
-
<!--
+
==The solution structure of molt-inhibiting hormone from the kuruma prawn==
-
The line below this paragraph, containing "STRUCTURE_1j0t", creates the "Structure Box" on the page.
+
<StructureSection load='1j0t' size='340' side='right'caption='[[1j0t]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1j0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Penaeus_japonicus Penaeus japonicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J0T FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0t OCA], [https://pdbe.org/1j0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j0t RCSB], [https://www.ebi.ac.uk/pdbsum/1j0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0t ProSAT]</span></td></tr>
-
{{STRUCTURE_1j0t| PDB=1j0t | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MIH_PENJP MIH_PENJP] Inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops. Has little or no hyperglycemic activity.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/1j0t_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j0t ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Molting in crustaceans is controlled by molt-inhibiting hormone (MIH) and ecdysteroids. It is presumed that MIH inhibits the synthesis and the secretion of ecdysteroids by the Y-organ, resulting in molt suppression. The amino acid sequence of MIH is similar to that of crustacean hyperglycemic hormone (CHH), and therefore, they form a peptide family referred to as the CHH family. Most of the CHH family peptides show no cross-activity, whereas a few peptides show multiple hormonal activities. To reveal the structural basis of this functional specificity, we determined the solution structure of MIH from the Kuruma prawn Marsupenaeus japonicus and compared the solution structure of MIH with a homology-modeled structure of M. japonicus CHH. The solution structure of MIH consisted of five alpha-helices and no beta-structures, constituting a novel structural motif. The homology-modeled structure of M. japonicus CHH was very similar to the solution structure of MIH with the exception of the absence of the N-terminal alpha-helix and the C-terminal tail, which were sterically close to each other. The surface properties of MIH around this region were quite different from those of CHH. These results strongly suggest that this region is a functionally important site for conferring molt-inhibiting activity.
-
===The solution structure of molt-inhibiting hormone from the kuruma prawn===
+
The solution structure of molt-inhibiting hormone from the Kuruma prawn Marsupenaeus japonicus.,Katayama H, Nagata K, Ohira T, Yumoto F, Tanokura M, Nagasawa H J Biol Chem. 2003 Mar 14;278(11):9620-3. Epub 2003 Jan 7. PMID:12519766<ref>PMID:12519766</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12519766}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1j0t" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12519766 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12519766}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1J0T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Marsupenaeus_japonicus Marsupenaeus japonicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0T OCA].
+
[[Category: Penaeus japonicus]]
-
 
+
[[Category: Katayama H]]
-
==Reference==
+
[[Category: Nagasawa H]]
-
<ref group="xtra">PMID:12519766</ref><references group="xtra"/>
+
[[Category: Nagata K]]
-
[[Category: Marsupenaeus japonicus]]
+
[[Category: Ohira T]]
-
[[Category: Katayama, H.]]
+
[[Category: Tanokura M]]
-
[[Category: Nagasawa, H.]]
+
[[Category: Yumoto F]]
-
[[Category: Nagata, K.]]
+
-
[[Category: Ohira, T.]]
+
-
[[Category: Tanokura, M.]]
+
-
[[Category: Yumoto, F.]]
+
-
[[Category: Alpha-helical protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:23:44 2009''
+

Current revision

The solution structure of molt-inhibiting hormone from the kuruma prawn

PDB ID 1j0t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j0t"
Personal tools