3eah

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:46, 21 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3eah.png|left|200px]]
 
-
<!--
+
==Structure of inhibited human eNOS oxygenase domain==
-
The line below this paragraph, containing "STRUCTURE_3eah", creates the "Structure Box" on the page.
+
<StructureSection load='3eah' size='340' side='right'caption='[[3eah]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3eah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=327:(3S,5E)-3-PROPYL-3,4-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5(2H)-IMINE'>327</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_3eah| PDB=3eah | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eah OCA], [https://pdbe.org/3eah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eah RCSB], [https://www.ebi.ac.uk/pdbsum/3eah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eah ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eah_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eah ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of inhibited human eNOS oxygenase domain===
+
==See Also==
-
 
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_18849972}}
+
-
 
+
-
==About this Structure==
+
-
3EAH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18849972</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Large Structures]]
-
[[Category: Aberg, A.]]
+
[[Category: Aberg A]]
-
[[Category: Andersson, G.]]
+
[[Category: Andersson G]]
-
[[Category: Andrews, G.]]
+
[[Category: Andrews G]]
-
[[Category: Arvai, A S.]]
+
[[Category: Arvai AS]]
-
[[Category: Cheshire, D R.]]
+
[[Category: Cheshire DR]]
-
[[Category: Connolly, S.]]
+
[[Category: Connolly S]]
-
[[Category: Crane, B R.]]
+
[[Category: Crane BR]]
-
[[Category: Garcin, E D.]]
+
[[Category: Garcin ED]]
-
[[Category: Gensmantel, N P.]]
+
[[Category: Gensmantel NP]]
-
[[Category: Getzoff, E D.]]
+
[[Category: Getzoff ED]]
-
[[Category: Hamley, P J.]]
+
[[Category: Hamley PJ]]
-
[[Category: Kroeger, M D.]]
+
[[Category: Kroeger MD]]
-
[[Category: Mallinder, P R.]]
+
[[Category: Mallinder PR]]
-
[[Category: Mete, A.]]
+
[[Category: Mete A]]
-
[[Category: Nicholls, D J.]]
+
[[Category: Nicholls DJ]]
-
[[Category: Rosenfeld, R J.]]
+
[[Category: Rosenfeld RJ]]
-
[[Category: St-Gallay, S A.]]
+
[[Category: St-Gallay SA]]
-
[[Category: Stuehr, D J.]]
+
[[Category: Stuehr DJ]]
-
[[Category: Tainer, J A.]]
+
[[Category: Tainer JA]]
-
[[Category: Tinker, A C.]]
+
[[Category: Tinker AC]]
-
[[Category: Wallace, A V.]]
+
[[Category: Wallace AV]]
-
[[Category: Fad]]
+
-
[[Category: Fmn]]
+
-
[[Category: Heme]]
+
-
[[Category: Iron]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nadp]]
+
-
[[Category: Nitric oxide synthase]]
+
-
[[Category: No]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Oxidoreductase calmodulin-binding]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Tetrahydrobiopterin]]
+
-
[[Category: Zinc]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:33:07 2009''
+

Current revision

Structure of inhibited human eNOS oxygenase domain

PDB ID 3eah

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3eah"
Personal tools