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2uug

From Proteopedia

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{{Seed}}
 
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[[Image:2uug.png|left|200px]]
 
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==ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI==
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The line below this paragraph, containing "STRUCTURE_2uug", creates the "Structure Box" on the page.
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<StructureSection load='2uug' size='340' side='right'caption='[[2uug]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2uug]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBS2 Bacillus phage PBS2] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UUG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uug OCA], [https://pdbe.org/2uug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uug RCSB], [https://www.ebi.ac.uk/pdbsum/2uug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uug ProSAT]</span></td></tr>
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{{STRUCTURE_2uug| PDB=2uug | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UNG_ECOLI UNG_ECOLI] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_00148]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uu/2uug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uug ConSurf].
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<div style="clear:both"></div>
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===ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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*[[Uracil glycosylase inhibitor|Uracil glycosylase inhibitor]]
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_10080896}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 10080896 is the PubMed ID number.
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[[Category: Bacillus phage PBS2]]
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[[Category: Escherichia coli K-12]]
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{{ABSTRACT_PUBMED_10080896}}
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[[Category: Large Structures]]
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[[Category: Arvai AS]]
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==About this Structure==
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[[Category: Mol CD]]
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2UUG is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_phage_pbs2 Bacillus phage pbs2] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUG OCA].
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[[Category: Putnam CD]]
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[[Category: Tainer JA]]
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==Reference==
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<ref group="xtra">PMID:10080896</ref><references group="xtra"/>
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[[Category: Bacillus phage pbs2]]
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[[Category: Escherichia coli]]
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[[Category: Uridine nucleosidase]]
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[[Category: Arvai, A S.]]
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[[Category: Mol, C D.]]
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[[Category: Putnam, C D.]]
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[[Category: Tainer, J A.]]
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[[Category: Dna base excision repair]]
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[[Category: Protein inhibitor]]
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[[Category: Protein mimicry of dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:35:52 2009''
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Current revision

ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI

PDB ID 2uug

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