Template:STRUCTURE 1v4s
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{{Structure | {{Structure | ||
- | |PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1v4s]], resolution 2.30Å (<scene name='initialview01'>default scene</scene>)}}} | + | |PDB= {{{PDB}}}|SCENE={{{SCENE|}}}|SIZE={{{SIZE|350}}}|CAPTION={{{CAPTION|[[1v4s]], [[Resolution|resolution]] 2.30Å (<scene name='initialview01'>default scene</scene>)}}} |
- | |LIGAND= <scene name='pdbligand=GLC: | + | |LIGAND= <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MRK:2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE'>MRK</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> |
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span> | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span> | ||
- | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00349 Hexokinase_1], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03727 Hexokinase_2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5026 COG5026]</span> | ||
|RELATEDENTRY=[[1v4t|1v4t]] | |RELATEDENTRY=[[1v4t|1v4t]] | ||
- | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4s OCA], [http://www. | + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v4s RCSB], [http://www.ebi.ac.uk/pdbsum/1v4s PDBsum]</span> |
|FUNCTION={{GO|id=GO:0004340 | text = glucokinase activity}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0004396 | text = hexokinase activity}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0005536 | text = glucose binding}} | |FUNCTION={{GO|id=GO:0004340 | text = glucokinase activity}}{{GO|id=GO:0016301 | text = kinase activity}}{{GO|id=GO:0000166 | text = nucleotide binding}}{{GO|id=GO:0004396 | text = hexokinase activity}}{{GO|id=GO:0016740 | text = transferase activity}}{{GO|id=GO:0005524 | text = ATP binding}}{{GO|id=GO:0005515 | text = protein binding}}{{GO|id=GO:0005536 | text = glucose binding}} | ||
|PROCESS={{GO|id=GO:0042593 | text = glucose homeostasis}}{{GO|id=GO:0051594 | text = detection of glucose}}{{GO|id=GO:0045725 | text = positive regulation of glycogen biosynthetic process}}{{GO|id=GO:0006006 | text = glucose metabolic process}}{{GO|id=GO:0006096 | text = glycolysis}}{{GO|id=GO:0045721 | text = negative regulation of gluconeogenesis}}{{GO|id=GO:0032024 | text = positive regulation of insulin secretion}} | |PROCESS={{GO|id=GO:0042593 | text = glucose homeostasis}}{{GO|id=GO:0051594 | text = detection of glucose}}{{GO|id=GO:0045725 | text = positive regulation of glycogen biosynthetic process}}{{GO|id=GO:0006006 | text = glucose metabolic process}}{{GO|id=GO:0006096 | text = glycolysis}}{{GO|id=GO:0045721 | text = negative regulation of gluconeogenesis}}{{GO|id=GO:0032024 | text = positive regulation of insulin secretion}} | ||
|SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001312 Ipr001312]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00349 PF00349], [http://pfam.sanger.ac.uk/family?acc=PF03727 PF03727]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&key=100310 d1v4sa2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&key=100309 d1v4sa1]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P35557 P35557]</span> | |SARESOURCES=<span class='plainlinks'>InterPro : [http://www.ebi.ac.uk/interpro/ISearch?query=IPR001312 Ipr001312]<br>Pfam : [http://pfam.sanger.ac.uk/family?acc=PF00349 PF00349], [http://pfam.sanger.ac.uk/family?acc=PF03727 PF03727]<br>SCOP : [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&key=100310 d1v4sa2], [http://scop.mrc-lmb.cam.ac.uk/scop/search.cgi?search_type=SCOP&key=100309 d1v4sa1]<br>UniProt : [http://ca.expasy.org/cgi-bin/niceprot.pl?P35557 P35557]</span> | ||
- | | | + | |uPDB=1V4S|CONSURF={{!}}- |
- | |CONSURF={{!}}- | + | |
{{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]] | {{!}} colspan="2" style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" {{!}} [[Image:Consurf_key_small.gif|center]] | ||
{{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" | {{!}}-{{!}} style="background-color:#bac9f7;color:#040d44;vertical-align:top;text-align:left;" |
Current revision
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1v4s, resolution 2.30Å () | |||||||||
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Ligands: | , , | ||||||||
Activity: | Hexokinase, with EC number 2.7.1.1 | ||||||||
Related: | 1v4t | ||||||||
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Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
Coordinates: | save as pdb, mmCIF, xml |