1nr1

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{{Seed}}
 
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[[Image:1nr1.png|left|200px]]
 
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==Crystal structure of the R463A mutant of human Glutamate dehydrogenase==
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The line below this paragraph, containing "STRUCTURE_1nr1", creates the "Structure Box" on the page.
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<StructureSection load='1nr1' size='340' side='right'caption='[[1nr1]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nr1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NR1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr1 OCA], [https://pdbe.org/1nr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nr1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr1 ProSAT]</span></td></tr>
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{{STRUCTURE_1nr1| PDB=1nr1 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DHE3_HUMAN DHE3_HUMAN] Defects in GLUD1 are the cause of familial hyperinsulinemic hypoglycemia type 6 (HHF6) [MIM:[https://omim.org/entry/606762 606762]; also known as hyperinsulinism-hyperammonemia syndrome (HHS). Familial hyperinsulinemic hypoglycemia [MIM:[https://omim.org/entry/256450 256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. In HHF6 elevated oxidation rate of glutamate to alpha-ketoglutarate stimulates insulin secretion in the pancreatic beta cells, while they impair detoxification of ammonium in the liver.<ref>PMID:9571255</ref> <ref>PMID:10636977</ref> <ref>PMID:11214910</ref> <ref>PMID:11297618</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DHE3_HUMAN DHE3_HUMAN] May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nr1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nr1 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the R463A mutant of human Glutamate dehydrogenase===
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==See Also==
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*[[Glutamate dehydrogenase 3D structures|Glutamate dehydrogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12653548 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12653548}}
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==About this Structure==
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1NR1 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR1 OCA].
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==Reference==
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<ref group="xtra">PMID:12653548</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banerjee, S.]]
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[[Category: Large Structures]]
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[[Category: Fang, J]]
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[[Category: Banerjee S]]
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[[Category: Schmidt, T.]]
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[[Category: Fang J]]
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[[Category: Smith, T J.]]
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[[Category: Schmidt T]]
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[[Category: Stanley, C A.]]
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[[Category: Smith TJ]]
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[[Category: Glutamate dehydrogenase]]
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[[Category: Stanley CA]]
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[[Category: Hexamer]]
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[[Category: Regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:42:30 2009''
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Current revision

Crystal structure of the R463A mutant of human Glutamate dehydrogenase

PDB ID 1nr1

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OCA

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