1eym

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{{Seed}}
 
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[[Image:1eym.png|left|200px]]
 
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==FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1eym", creates the "Structure Box" on the page.
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<StructureSection load='1eym' size='340' side='right'caption='[[1eym]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1eym]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EYM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eym OCA], [https://pdbe.org/1eym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eym RCSB], [https://www.ebi.ac.uk/pdbsum/1eym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eym ProSAT]</span></td></tr>
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{{STRUCTURE_1eym| PDB=1eym | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1eym_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eym ConSurf].
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<div style="clear:both"></div>
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===FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX===
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==See Also==
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10852943}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10852943 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10852943}}
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==About this Structure==
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1EYM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYM OCA].
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==Reference==
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<ref group="xtra">PMID:10852943</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Adams, S E.]]
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[[Category: Adams SE]]
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[[Category: Andrade, L J.]]
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[[Category: Andrade LJ]]
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[[Category: Clackson, T.]]
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[[Category: Clackson T]]
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[[Category: Gilman, M.]]
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[[Category: Gilman M]]
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[[Category: Hatada, M.]]
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[[Category: Hatada M]]
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[[Category: Holt, D A.]]
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[[Category: Holt DA]]
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[[Category: Keenan, T.]]
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[[Category: Keenan T]]
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[[Category: Rivera, V M.]]
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[[Category: Rivera VM]]
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[[Category: Rollins, C T.]]
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[[Category: Rollins CT]]
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[[Category: Schravendijk, M R.van.]]
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[[Category: Woolfson DN]]
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[[Category: Woolfson, D N.]]
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[[Category: Yaeger D]]
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[[Category: Yaeger, D.]]
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[[Category: Van Schravendijk MR]]
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[[Category: Isomerase]]
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[[Category: Ligand-reversible dimer]]
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[[Category: Rotamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:47:38 2009''
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Current revision

FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX

PDB ID 1eym

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