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1fsb

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{{Seed}}
 
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[[Image:1fsb.png|left|200px]]
 
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==STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1fsb", creates the "Structure Box" on the page.
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<StructureSection load='1fsb' size='340' side='right'caption='[[1fsb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FSB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fsb OCA], [https://pdbe.org/1fsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fsb RCSB], [https://www.ebi.ac.uk/pdbsum/1fsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fsb ProSAT]</span></td></tr>
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{{STRUCTURE_1fsb| PDB=1fsb | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LYAM3_HUMAN LYAM3_HUMAN] Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LYAM3_HUMAN LYAM3_HUMAN] Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.<ref>PMID:7585950</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fsb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fsb ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES===
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==See Also==
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*[[Selectin|Selectin]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8901515}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8901515 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_8901515}}
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==About this Structure==
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1FSB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSB OCA].
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==Reference==
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<ref group="xtra">PMID:8901515</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bachovchin, W W.]]
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[[Category: Large Structures]]
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[[Category: Baleja, J D.]]
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[[Category: Bachovchin WW]]
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[[Category: Freedman, S J.]]
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[[Category: Baleja JD]]
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[[Category: Furie, B.]]
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[[Category: Freedman SJ]]
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[[Category: Furie, B C.]]
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[[Category: Furie B]]
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[[Category: Sanford, D G.]]
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[[Category: Furie BC]]
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[[Category: Cell adhesion protein]]
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[[Category: Sanford DG]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:57:11 2009''
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Current revision

STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES

PDB ID 1fsb

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