2jz3

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{{Seed}}
 
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[[Image:2jz3.png|left|200px]]
 
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==SOCS box elonginBC ternary complex==
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The line below this paragraph, containing "STRUCTURE_2jz3", creates the "Structure Box" on the page.
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<StructureSection load='2jz3' size='340' side='right'caption='[[2jz3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jz3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JZ3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jz3 OCA], [https://pdbe.org/2jz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2jz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jz3 ProSAT]</span></td></tr>
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{{STRUCTURE_2jz3| PDB=2jz3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SOCS3_MOUSE SOCS3_MOUSE] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to recognize IL6ST.<ref>PMID:9889194</ref> <ref>PMID:10821852</ref> <ref>PMID:10490101</ref> <ref>PMID:12754505</ref> <ref>PMID:12847520</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/2jz3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jz3 ConSurf].
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<div style="clear:both"></div>
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===SOCS box elonginBC ternary complex===
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==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18590740 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18590740}}
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==About this Structure==
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2JZ3 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JZ3 OCA].
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==Reference==
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<ref group="xtra">PMID:18590740</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Babon, J J.]]
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[[Category: Babon JJ]]
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[[Category: Bailey, M F.]]
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[[Category: Bailey MF]]
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[[Category: Nicola, N A.]]
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[[Category: Nicola NA]]
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[[Category: Norton, R S.]]
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[[Category: Norton RS]]
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[[Category: Sabo, J.]]
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[[Category: Sabo J]]
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[[Category: Soetopo, A.]]
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[[Category: Soetopo A]]
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[[Category: Yao, S.]]
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[[Category: Yao S]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Acetylation]]
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[[Category: Cytokine signaling]]
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[[Category: Elongin]]
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[[Category: Growth regulation]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sh2 domain]]
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[[Category: Signal transduction inhibitor]]
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[[Category: Signaling protein]]
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[[Category: Socs protein]]
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[[Category: Transcription]]
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[[Category: Transcription inhibitor/transcription complex]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:03:11 2009''
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Current revision

SOCS box elonginBC ternary complex

PDB ID 2jz3

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