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2op7

From Proteopedia

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{{Seed}}
 
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[[Image:2op7.png|left|200px]]
 
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<!--
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==WW4==
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The line below this paragraph, containing "STRUCTURE_2op7", creates the "Structure Box" on the page.
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<StructureSection load='2op7' size='340' side='right'caption='[[2op7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2op7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OP7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2op7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2op7 OCA], [https://pdbe.org/2op7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2op7 RCSB], [https://www.ebi.ac.uk/pdbsum/2op7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2op7 ProSAT]</span></td></tr>
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{{STRUCTURE_2op7| PDB=2op7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WWP1_HUMAN WWP1_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.<ref>PMID:15359284</ref> <ref>PMID:15221015</ref> <ref>PMID:12535537</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/2op7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2op7 ConSurf].
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<div style="clear:both"></div>
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===WW4===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2OP7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP7 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ahmed, S.]]
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[[Category: Large Structures]]
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[[Category: Li, M F.]]
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[[Category: Ahmed S]]
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[[Category: Pu, H.]]
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[[Category: Li MF]]
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[[Category: Qin, H N.]]
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[[Category: Pu H]]
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[[Category: Sankaran, S.]]
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[[Category: Qin HN]]
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[[Category: Song, J X.]]
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[[Category: Sankaran S]]
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[[Category: Beta sheet]]
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[[Category: Song JX]]
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[[Category: Ligase]]
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[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:12:36 2009''
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Current revision

WW4

PDB ID 2op7

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