1r8n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:18, 30 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1r8n.png|left|200px]]
 
-
<!--
+
==The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia==
-
The line below this paragraph, containing "STRUCTURE_1r8n", creates the "Structure Box" on the page.
+
<StructureSection load='1r8n' size='340' side='right'caption='[[1r8n]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1r8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Delonix_regia Delonix regia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8N FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8n OCA], [https://pdbe.org/1r8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8n RCSB], [https://www.ebi.ac.uk/pdbsum/1r8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8n ProSAT]</span></td></tr>
-
{{STRUCTURE_1r8n| PDB=1r8n | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DRTI_DELRE DRTI_DELRE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8n_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8n ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The three-dimensional structure of a novel Kunitz (STI) family member, an inhibitor purified from Delonix regia seeds (DrTI), was solved by molecular replacement method and refined, respectively, to R(factor) and R(free) values of 21.5% and 25.3% at 1.75A resolution. The structure has a classical beta-trefoil fold, however, differently from canonical Kunitz type (STI) inhibitors, its reactive site loop has an insertion of one residue, Glu68, between the residues P1 and P2. Surprisingly, DrTI is an effective inhibitor of trypsin and human plasma kallikrein, but not of chymotrypsin and tissue kallikrein. Putative structural grounds of such specificity are discussed.
-
===The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia===
+
Crystal structure of the Kunitz (STI)-type inhibitor from Delonix regia seeds.,Krauchenco S, Pando SC, Marangoni S, Polikarpov I Biochem Biophys Res Commun. 2003 Dec 26;312(4):1303-8. PMID:14652016<ref>PMID:14652016</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1r8n" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_14652016}}, adds the Publication Abstract to the page
+
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 14652016 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_14652016}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1R8N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Delonix_regia Delonix regia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8N OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:14652016</ref><references group="xtra"/>
+
[[Category: Delonix regia]]
[[Category: Delonix regia]]
-
[[Category: Krauchenco, S.]]
+
[[Category: Large Structures]]
-
[[Category: Marangoni, S.]]
+
[[Category: Krauchenco S]]
-
[[Category: Pando, S C.]]
+
[[Category: Marangoni S]]
-
[[Category: Polikarpov, I.]]
+
[[Category: Pando SC]]
-
[[Category: Beta-trefoil fold]]
+
[[Category: Polikarpov I]]
-
[[Category: Delonix regia]]
+
-
[[Category: Flamboyant]]
+
-
[[Category: Kunitz-type trypsin/kallikrein inhibitor]]
+
-
[[Category: X-ray structure]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:17:31 2009''
+

Current revision

The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia

PDB ID 1r8n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r8n"
Personal tools