1jh1

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{{Seed}}
 
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[[Image:1jh1.png|left|200px]]
 
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==Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor==
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The line below this paragraph, containing "STRUCTURE_1jh1", creates the "Structure Box" on the page.
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<StructureSection load='1jh1' size='340' side='right'caption='[[1jh1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JH1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JST:BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE'>JST</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1jh1| PDB=1jh1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jh1 OCA], [https://pdbe.org/1jh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jh1 RCSB], [https://www.ebi.ac.uk/pdbsum/1jh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jh1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jh1 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor===
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11563922}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11563922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11563922}}
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==About this Structure==
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1JH1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JH1 OCA].
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==Reference==
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<ref group="xtra">PMID:11563922</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Neutrophil collagenase]]
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[[Category: Large Structures]]
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[[Category: Brandstetter, H.]]
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[[Category: Brandstetter H]]
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[[Category: Henke, A.]]
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[[Category: Henke A]]
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[[Category: Pfeiffer, W D.]]
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[[Category: Pfeiffer WD]]
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[[Category: Schroder, J.]]
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[[Category: Schroder J]]
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[[Category: Stammler, A.]]
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[[Category: Stammler A]]
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[[Category: Stammler, H G.]]
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[[Category: Stammler HG]]
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[[Category: Tschesche, H.]]
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[[Category: Tschesche H]]
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[[Category: Wenzel, H.]]
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[[Category: Wenzel H]]
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[[Category: Collagenase]]
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[[Category: Inhibitor]]
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[[Category: Thiadiazine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:21:33 2009''
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Current revision

Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor

PDB ID 1jh1

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