1ore

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:02, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ore.png|left|200px]]
 
-
<!--
+
==Human Adenine Phosphoribosyltransferase==
-
The line below this paragraph, containing "STRUCTURE_1ore", creates the "Structure Box" on the page.
+
<StructureSection load='1ore' size='340' side='right'caption='[[1ore]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ore]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
{{STRUCTURE_1ore| PDB=1ore | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ore FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ore OCA], [https://pdbe.org/1ore PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ore RCSB], [https://www.ebi.ac.uk/pdbsum/1ore PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ore ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[https://omim.org/entry/614723 614723]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref> <ref>PMID:7915931</ref> <ref>PMID:3680503</ref> <ref>PMID:3343350</ref> <ref>PMID:1353080</ref> <ref>PMID:11243733</ref> <ref>PMID:15571218</ref> <ref>PMID:21635362</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1ore_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ore ConSurf].
 +
<div style="clear:both"></div>
-
===Human Adenine Phosphoribosyltransferase===
+
==See Also==
-
 
+
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15196008}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 15196008 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_15196008}}
+
-
 
+
-
==Disease==
+
-
Known disease associated with this structure: Urolithiasis, 2,8-dihydroxyadenine OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102600 102600]]
+
-
 
+
-
==About this Structure==
+
-
1ORE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORE OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15196008</ref><references group="xtra"/>
+
-
[[Category: Adenine phosphoribosyltransferase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Iulek, J.]]
+
[[Category: Large Structures]]
-
[[Category: Oliva, G.]]
+
[[Category: Iulek J]]
-
[[Category: Silva, C H.T P.]]
+
[[Category: Oliva G]]
-
[[Category: Silva, M.]]
+
[[Category: Silva CHTP]]
-
[[Category: Thiemann, O H.]]
+
[[Category: Silva M]]
-
[[Category: Glycosyl transferase]]
+
[[Category: Thiemann OH]]
-
[[Category: Human adenine phosphoribosyltransferase]]
+
-
[[Category: Leishmaniasis]]
+
-
[[Category: Purine salvage]]
+
-
[[Category: Urolithiasis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:25:47 2009''
+

Current revision

Human Adenine Phosphoribosyltransferase

PDB ID 1ore

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ore"
Personal tools