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1ore

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{{Seed}}
 
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[[Image:1ore.png|left|200px]]
 
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<!--
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==Human Adenine Phosphoribosyltransferase==
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The line below this paragraph, containing "STRUCTURE_1ore", creates the "Structure Box" on the page.
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<StructureSection load='1ore' size='340' side='right'caption='[[1ore]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ore]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ORE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1ore| PDB=1ore | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ore FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ore OCA], [https://pdbe.org/1ore PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ore RCSB], [https://www.ebi.ac.uk/pdbsum/1ore PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ore ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD) [MIM:[https://omim.org/entry/614723 614723]; also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones.<ref>PMID:1746557</ref> <ref>PMID:7915931</ref> <ref>PMID:3680503</ref> <ref>PMID:3343350</ref> <ref>PMID:1353080</ref> <ref>PMID:11243733</ref> <ref>PMID:15571218</ref> <ref>PMID:21635362</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/APT_HUMAN APT_HUMAN] Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/or/1ore_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ore ConSurf].
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<div style="clear:both"></div>
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===Human Adenine Phosphoribosyltransferase===
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15196008}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15196008 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15196008}}
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==Disease==
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Known disease associated with this structure: Urolithiasis, 2,8-dihydroxyadenine OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102600 102600]]
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==About this Structure==
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1ORE is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ORE OCA].
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==Reference==
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<ref group="xtra">PMID:15196008</ref><references group="xtra"/>
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[[Category: Adenine phosphoribosyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Iulek, J.]]
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[[Category: Large Structures]]
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[[Category: Oliva, G.]]
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[[Category: Iulek J]]
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[[Category: Silva, C H.T P.]]
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[[Category: Oliva G]]
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[[Category: Silva, M.]]
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[[Category: Silva CHTP]]
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[[Category: Thiemann, O H.]]
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[[Category: Silva M]]
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[[Category: Glycosyl transferase]]
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[[Category: Thiemann OH]]
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[[Category: Human adenine phosphoribosyltransferase]]
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[[Category: Leishmaniasis]]
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[[Category: Purine salvage]]
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[[Category: Urolithiasis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:25:47 2009''
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Current revision

Human Adenine Phosphoribosyltransferase

PDB ID 1ore

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