1zta

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{{Seed}}
 
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[[Image:1zta.png|left|200px]]
 
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==THE SOLUTION STRUCTURE OF A LEUCINE-ZIPPER MOTIF PEPTIDE==
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The line below this paragraph, containing "STRUCTURE_1zta", creates the "Structure Box" on the page.
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<StructureSection load='1zta' size='340' side='right'caption='[[1zta]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZTA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zta OCA], [https://pdbe.org/1zta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zta RCSB], [https://www.ebi.ac.uk/pdbsum/1zta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zta ProSAT]</span></td></tr>
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{{STRUCTURE_1zta| PDB=1zta | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/1zta_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zta ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the complete structure determination of a 34 residue synthetic peptide with the amino acid sequence of the dimerization domain (leucine zipper) of GCN4. A high resolution structure in solution was obtained by 1H-NMR studies and distance geometry calculations followed by restrained energy minimization. A set of 20 final structures was obtained with an average root mean square deviation of 1.3 A for the backbone atoms (excluding the first and the last two residues). The structure contains an uninterrupted helix. A comparison with a structure previously determined for a larger peptide containing both the DNA-binding region (basic region) and the leucine-zipper motif shows the structural independence of the leucine-zipper domain from the contiguous DNA binding region.
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===THE SOLUTION STRUCTURE OF A LEUCINE-ZIPPER MOTIF PEPTIDE===
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The solution structure of a leucine-zipper motif peptide.,Saudek V, Pastore A, Morelli MA, Frank R, Gausepohl H, Gibson T Protein Eng. 1991 Jun;4(5):519-29. PMID:1891459<ref>PMID:1891459</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_1891459}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zta" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 1891459 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_1891459}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1ZTA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTA OCA].
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==Reference==
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<ref group="xtra">PMID:1891459</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Frank, R.]]
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[[Category: Castiglione Morelli MA]]
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[[Category: Gausepohl, H.]]
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[[Category: Frank R]]
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[[Category: Gibson, T.]]
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[[Category: Gausepohl H]]
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[[Category: Morelli, M A.Castiglione.]]
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[[Category: Gibson T]]
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[[Category: Pastore, A.]]
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[[Category: Pastore A]]
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[[Category: Saudek, V.]]
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[[Category: Saudek V]]
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[[Category: Dna-binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:38:12 2009''
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Current revision

THE SOLUTION STRUCTURE OF A LEUCINE-ZIPPER MOTIF PEPTIDE

PDB ID 1zta

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