2j8i

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{{Seed}}
 
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[[Image:2j8i.png|left|200px]]
 
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==Structure of NP275, a pentapeptide repeat protein from Nostoc punctiforme==
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The line below this paragraph, containing "STRUCTURE_2j8i", creates the "Structure Box" on the page.
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<StructureSection load='2j8i' size='340' side='right'caption='[[2j8i]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2j8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_2j8i| PDB=2j8i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8i OCA], [https://pdbe.org/2j8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8i RCSB], [https://www.ebi.ac.uk/pdbsum/2j8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8i ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j8i ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.
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===STRUCTURE OF NP275, A PENTAPEPTIDE REPEAT PROTEIN FROM NOSTOC PUNCTIFORME===
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Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.,Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236<ref>PMID:17384236</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17384236}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2j8i" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17384236 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17384236}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2J8I is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8I OCA].
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==Reference==
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<ref group="xtra">PMID:17384236</ref><references group="xtra"/>
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[[Category: Nostoc punctiforme]]
[[Category: Nostoc punctiforme]]
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[[Category: Blanchard, J S.]]
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[[Category: Blanchard JS]]
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[[Category: Hazleton, K Z.]]
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[[Category: Hazleton KZ]]
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[[Category: Hegde, S S.]]
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[[Category: Hegde SS]]
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[[Category: Vetting, M W.]]
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[[Category: Vetting MW]]
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[[Category: Nostoc punctiforme]]
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[[Category: Pentapeptide repeat protein]]
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[[Category: Prp]]
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[[Category: Rhqbh]]
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[[Category: Right handed quadrilateral beta helix]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:40:38 2009''
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Current revision

Structure of NP275, a pentapeptide repeat protein from Nostoc punctiforme

PDB ID 2j8i

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