1g1j

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{{Seed}}
 
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[[Image:1g1j.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE OLIGOMERIZATION DOMAIN FROM ROTAVIRUS NSP4==
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The line below this paragraph, containing "STRUCTURE_1g1j", creates the "Structure Box" on the page.
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<StructureSection load='1g1j' size='340' side='right'caption='[[1g1j]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_rotavirus_A/SA11 Simian rotavirus A/SA11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G1J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
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{{STRUCTURE_1g1j| PDB=1g1j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g1j OCA], [https://pdbe.org/1g1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g1j RCSB], [https://www.ebi.ac.uk/pdbsum/1g1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g1j ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF THE OLIGOMERIZATION DOMAIN FROM ROTAVIRUS NSP4===
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== Function ==
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[https://www.uniprot.org/uniprot/NSP4_ROTS1 NSP4_ROTS1] Plays an essential role in the virus replication cycle by acting as a viroporin. Creates a pore in the host reticulum endoplasmic and as a consequence releases Ca(2+) in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication and immature particle assembly.[HAMAP-Rule:MF_04091]<ref>PMID:21151776</ref> <ref>PMID:7637021</ref> <ref>PMID:9108087</ref> The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.[HAMAP-Rule:MF_04091]<ref>PMID:17035333</ref> <ref>PMID:18587047</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11124032}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11124032 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g1/1g1j_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11124032}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1G1J is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G1J OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g1j ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:11124032</ref><references group="xtra"/>
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<references/>
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[[Category: Bowman, G D.]]
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__TOC__
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[[Category: Nodelman, I M.]]
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</StructureSection>
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[[Category: Schutt, C E.]]
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[[Category: Large Structures]]
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[[Category: Cation]]
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[[Category: Simian rotavirus A/SA11]]
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[[Category: Homo-tetramer]]
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[[Category: Bowman GD]]
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[[Category: Metal binding site]]
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[[Category: Nodelman IM]]
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[[Category: Ns28]]
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[[Category: Schutt CE]]
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[[Category: Parallel coiled-coil]]
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[[Category: Strontium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:45:41 2009''
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Current revision

CRYSTAL STRUCTURE OF THE OLIGOMERIZATION DOMAIN FROM ROTAVIRUS NSP4

PDB ID 1g1j

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