3dlq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:59, 30 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3dlq.png|left|200px]]
 
-
<!--
+
==Crystal structure of the IL-22/IL-22R1 complex==
-
The line below this paragraph, containing "STRUCTURE_3dlq", creates the "Structure Box" on the page.
+
<StructureSection load='3dlq' size='340' side='right'caption='[[3dlq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3dlq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DLQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlq OCA], [https://pdbe.org/3dlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dlq RCSB], [https://www.ebi.ac.uk/pdbsum/3dlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dlq ProSAT]</span></td></tr>
-
{{STRUCTURE_3dlq| PDB=3dlq | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/I22R1_HUMAN I22R1_HUMAN] Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.<ref>PMID:11035029</ref> <ref>PMID:11564763</ref> <ref>PMID:11706020</ref> <ref>PMID:12351624</ref> <ref>PMID:12941841</ref> <ref>PMID:17204547</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dlq_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dlq ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.
-
===Crystal structure of the IL-22/IL-22R1 complex===
+
Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.,Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I FEBS Lett. 2008 Sep 3;582(20):2985-92. Epub 2008 Aug 7. PMID:18675809<ref>PMID:18675809</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3dlq" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_18675809}}, adds the Publication Abstract to the page
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 18675809 is the PubMed ID number.
+
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_18675809}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
3DLQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLQ OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18675809</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bleicher, L.]]
+
[[Category: Large Structures]]
-
[[Category: Colau, D.]]
+
[[Category: Bleicher L]]
-
[[Category: Dumoutier, L.]]
+
[[Category: Colau D]]
-
[[Category: Moura, P R.de.]]
+
[[Category: Dumoutier L]]
-
[[Category: Polikarpov, I.]]
+
[[Category: Polikarpov I]]
-
[[Category: Renauld, J C.]]
+
[[Category: Renauld J-C]]
-
[[Category: Watanabe, L.]]
+
[[Category: Watanabe L]]
-
[[Category: Cytokine]]
+
[[Category: De Moura PR]]
-
[[Category: Cytokine-receptor complex]]
+
-
[[Category: Cytokine/cytokine receptor complex]]
+
-
[[Category: Fibronectin-iii]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Receptor]]
+
-
[[Category: Secreted]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:49:30 2009''
+

Current revision

Crystal structure of the IL-22/IL-22R1 complex

PDB ID 3dlq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3dlq"
Personal tools