2f3n

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(New page: 200px<br /><applet load="2f3n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f3n, resolution 2.1&Aring;" /> '''Crystal Structure of ...)
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[[Image:2f3n.gif|left|200px]]<br /><applet load="2f3n" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2f3n, resolution 2.1&Aring;" />
 
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'''Crystal Structure of the native Shank SAM domain.'''<br />
 
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==Overview==
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==Crystal Structure of the native Shank SAM domain.==
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The postsynaptic density (PSD) is a complex assembly of proteins, associated with the postsynaptic membrane that organizes neurotransmitter, receptors, signaling pathways, and regulatory elements within a, cytoskeletal matrix. Here we show that the sterile alpha motif domain of, rat Shank3/ProSAP2, a master scaffolding protein located deep within the, PSD, can form large sheets composed of helical fibers stacked side by, side. Zn2+, which is found in high concentrations in the PSD, binds, tightly to Shank3 and may regulate assembly. Sheets of the Shank protein, could form a platform for the construction of the PSD complex.
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<StructureSection load='2f3n' size='340' side='right'caption='[[2f3n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f3n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3n OCA], [https://pdbe.org/2f3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3n RCSB], [https://www.ebi.ac.uk/pdbsum/2f3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHAN3_RAT SHAN3_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3n ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2F3N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2F3N OCA].
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*[[Shank protein|Shank protein]]
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__TOC__
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==Reference==
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</StructureSection>
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An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16439662 16439662]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Baron MK]]
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[[Category: Baron, M.K.]]
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[[Category: Bowie JU]]
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[[Category: Bowie, J.U.]]
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[[Category: Faham S]]
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[[Category: Faham, S.]]
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[[Category: postsynaptic density]]
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[[Category: sam domain]]
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[[Category: scaffolding protein]]
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[[Category: shank]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:20:33 2007''
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Current revision

Crystal Structure of the native Shank SAM domain.

PDB ID 2f3n

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