2vyt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:37, 13 December 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2vyt.png|left|200px]]
 
-
<!--
+
==The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine.==
-
The line below this paragraph, containing "STRUCTURE_2vyt", creates the "Structure Box" on the page.
+
<StructureSection load='2vyt' size='340' side='right'caption='[[2vyt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2vyt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYT FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
{{STRUCTURE_2vyt| PDB=2vyt | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vyt OCA], [https://pdbe.org/2vyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vyt RCSB], [https://www.ebi.ac.uk/pdbsum/2vyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vyt ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SCML2_HUMAN SCML2_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vyt_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vyt ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
SCML2 (sex comb on midleg-like 2) is a constituent of the Polycomb repressive complex 1, a large multiprotein assembly required for the repression of developmental control genes. It contains two MBT (malignant brain tumor) repeats; the MBT is a protein module structurally similar to domains that bind to methylated histones. We have used NMR spectroscopy to examine the binding specificity of these repeats. Our data show that they preferentially bind histone peptides monomethylated at lysine residues with no apparent sequence specificity. The crystal structure of the complex between the protein and monomethyllysine reveals that the modified amino acid binds to an aromatic rich pocket at one end of the beta-barrel of the second repeat.
-
===THE MBT REPEATS OF HUMAN SCML2 BIND TO PEPTIDES CONTAINING MONO METHYLATED LYSINE.===
+
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.,Santiveri CM, Lechtenberg BC, Allen MD, Sathyamurthy A, Jaulent AM, Freund SM, Bycroft M J Mol Biol. 2008 Oct 24;382(5):1107-12. Epub 2008 Aug 3. PMID:18706910<ref>PMID:18706910</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18706910}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2vyt" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18706910 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_18706910}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2VYT is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYT OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:18706910</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Allen, M D.]]
+
[[Category: Large Structures]]
-
[[Category: Bycroft, M.]]
+
[[Category: Allen MD]]
-
[[Category: Freund, S M.V.]]
+
[[Category: Bycroft M]]
-
[[Category: Jaulent, A M.]]
+
[[Category: Freund SMV]]
-
[[Category: Lechtenberg, B C.]]
+
[[Category: Jaulent AM]]
-
[[Category: Santiveri, C M.]]
+
[[Category: Lechtenberg BC]]
-
[[Category: Sathyamurthy, A.]]
+
[[Category: Santiveri CM]]
-
[[Category: Alternative splicing]]
+
[[Category: Sathyamurthy A]]
-
[[Category: Chromatin]]
+
-
[[Category: Human scml2]]
+
-
[[Category: Mbt repeat]]
+
-
[[Category: Mono methylated peptide]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Repressor]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:11:07 2009''
+

Current revision

The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine.

PDB ID 2vyt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vyt"
Personal tools