2v1c

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{{Seed}}
 
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[[Image:2v1c.png|left|200px]]
 
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==Crystal structure and mutational study of RecOR provide insight into its role in DNA repair==
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The line below this paragraph, containing "STRUCTURE_2v1c", creates the "Structure Box" on the page.
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<StructureSection load='2v1c' size='340' side='right'caption='[[2v1c]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v1c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V1C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2v1c| PDB=2v1c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v1c OCA], [https://pdbe.org/2v1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v1c RCSB], [https://www.ebi.ac.uk/pdbsum/2v1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v1c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RECR_DEIRA RECR_DEIRA] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v1/2v1c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v1c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the complex formed between Deinococcus radiodurans RecR and RecO (drRecOR) has been determined. In accordance with previous biochemical characterisation, the drRecOR complex displays a RecR:RecO molecular ratio of 2:1. The biologically relevant drRecOR entity consists of a heterohexamer in the form of two drRecO molecules positioned on either side of the tetrameric ring of drRecR, with their OB (oligonucleotide/oligosaccharide-binding) domains pointing towards the interior of the ring. Mutagenesis studies validated the protein-protein interactions observed in the crystal structure and allowed mapping of the residues in the drRecOR complex required for DNA binding. Furthermore, the preferred DNA substrate of drRecOR was identified as being 3'-overhanging DNA, as encountered at ssDNA-dsDNA junctions. Together these results suggest a possible mechanism for drRecOR recognition of stalled replication forks.
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===CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR===
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Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding.,Timmins J, Leiros I, McSweeney S EMBO J. 2007 Jul 11;26(13):3260-71. Epub 2007 Jun 21. PMID:17581636<ref>PMID:17581636</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17581636}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2v1c" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17581636 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17581636}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Deinococcus radiodurans R1]]
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2V1C is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V1C OCA].
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[[Category: Large Structures]]
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[[Category: Leiros I]]
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==Reference==
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[[Category: McSweeney S]]
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<ref group="xtra">PMID:17581636</ref><references group="xtra"/>
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[[Category: Timmins J]]
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[[Category: Deinococcus radiodurans]]
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[[Category: Leiros, I.]]
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[[Category: Mcsweeney, S.]]
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[[Category: Timmins, J.]]
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[[Category: Deinococcus radioduran]]
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[[Category: Dna binding]]
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[[Category: Dna damage]]
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[[Category: Dna recombination]]
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[[Category: Dna repair]]
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[[Category: Homologous recombination]]
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[[Category: Hypothetical protein]]
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[[Category: Metal-binding]]
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[[Category: Recfor pathway]]
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[[Category: Reco]]
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[[Category: Recombination]]
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[[Category: Recor complex]]
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[[Category: Recr]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:20:27 2009''
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Current revision

Crystal structure and mutational study of RecOR provide insight into its role in DNA repair

PDB ID 2v1c

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