1cmv

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{{Seed}}
 
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[[Image:1cmv.png|left|200px]]
 
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==HUMAN CYTOMEGALOVIRUS PROTEASE==
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The line below this paragraph, containing "STRUCTURE_1cmv", creates the "Structure Box" on the page.
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<StructureSection load='1cmv' size='340' side='right'caption='[[1cmv]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cmv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CMV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmv OCA], [https://pdbe.org/1cmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cmv RCSB], [https://www.ebi.ac.uk/pdbsum/1cmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cmv ProSAT]</span></td></tr>
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{{STRUCTURE_1cmv| PDB=1cmv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/1cmv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cmv ConSurf].
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<div style="clear:both"></div>
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===HUMAN CYTOMEGALOVIRUS PROTEASE===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8805708}}, adds the Publication Abstract to the page
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[[Category: Human betaherpesvirus 5]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8805708 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Holwerda BC]]
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{{ABSTRACT_PUBMED_8805708}}
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[[Category: Kurumbail RG]]
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[[Category: Pak JY]]
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==About this Structure==
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[[Category: Palmier MO]]
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1CMV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMV OCA].
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[[Category: Shieh H-S]]
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[[Category: Stallings WC]]
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==Reference==
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[[Category: Stegeman RA]]
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<ref group="xtra">PMID:8805708</ref><references group="xtra"/>
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[[Category: Stevens AM]]
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[[Category: Human herpesvirus 5]]
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[[Category: Sturman EJ]]
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[[Category: Holwerda, B C.]]
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[[Category: Wiegand RC]]
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[[Category: Kurumbail, R G.]]
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[[Category: Wittwer AJ]]
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[[Category: Pak, J Y.]]
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[[Category: Palmier, M O.]]
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[[Category: Shieh, H S.]]
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[[Category: Stallings, W C.]]
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[[Category: Stegeman, R A.]]
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[[Category: Stevens, A M.]]
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[[Category: Sturman, E J.]]
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[[Category: Wiegand, R C.]]
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[[Category: Wittwer, A J.]]
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[[Category: Coat protein]]
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[[Category: Hydrolase]]
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[[Category: Phosphorylation]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:25:02 2009''
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Current revision

HUMAN CYTOMEGALOVIRUS PROTEASE

PDB ID 1cmv

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