1mq8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:39, 10 April 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1mq8.png|left|200px]]
 
-
<!--
+
==Crystal structure of alphaL I domain in complex with ICAM-1==
-
The line below this paragraph, containing "STRUCTURE_1mq8", creates the "Structure Box" on the page.
+
<StructureSection load='1mq8' size='340' side='right'caption='[[1mq8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1mq8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQ8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_1mq8| PDB=1mq8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq8 OCA], [https://pdbe.org/1mq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1mq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mq8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ICAM1_HUMAN ICAM1_HUMAN] ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.<ref>PMID:2538243</ref> <ref>PMID:1968231</ref> <ref>PMID:11173916</ref> <ref>PMID:17875742</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mq8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mq8 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of alphaL I domain in complex with ICAM-1===
+
==See Also==
-
 
+
*[[Integrin 3D structures|Integrin 3D structures]]
-
 
+
*[[Intercellular adhesion molecule|Intercellular adhesion molecule]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_12526797}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12526797 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_12526797}}
+
-
 
+
-
==About this Structure==
+
-
1MQ8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ8 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:12526797</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Dong, Y.]]
+
[[Category: Large Structures]]
-
[[Category: Joachimiak, A.]]
+
[[Category: Dong Y]]
-
[[Category: Jun, C D.]]
+
[[Category: Joachimiak A]]
-
[[Category: Liu, J H.]]
+
[[Category: Jun C-D]]
-
[[Category: McCormack, A.]]
+
[[Category: Liu J-H]]
-
[[Category: Shimaoka, M.]]
+
[[Category: McCormack A]]
-
[[Category: Springer, T A.]]
+
[[Category: Shimaoka M]]
-
[[Category: Takagi, J.]]
+
[[Category: Springer TA]]
-
[[Category: Wang, J H.]]
+
[[Category: Takagi J]]
-
[[Category: Xiao, T.]]
+
[[Category: Wang J-H]]
-
[[Category: Yang, Y.]]
+
[[Category: Xiao T]]
-
[[Category: Zhang, R.]]
+
[[Category: Yang Y]]
-
[[Category: Ig superfamily]]
+
[[Category: Zhang R]]
-
[[Category: Metal mediated protein interface]]
+
-
[[Category: Rossmann fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:26:15 2009''
+

Current revision

Crystal structure of alphaL I domain in complex with ICAM-1

PDB ID 1mq8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mq8"
Personal tools