2v42

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{{Seed}}
 
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[[Image:2v42.png|left|200px]]
 
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==Crystal structure of RseB: a sensor for periplasmic stress response in E. coli==
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The line below this paragraph, containing "STRUCTURE_2v42", creates the "Structure Box" on the page.
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<StructureSection load='2v42' size='340' side='right'caption='[[2v42]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2v42]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V42 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDS:ETHYL+DIMETHYL+AMMONIO+PROPANE+SULFONATE'>NDS</scene></td></tr>
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{{STRUCTURE_2v42| PDB=2v42 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v42 OCA], [https://pdbe.org/2v42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v42 RCSB], [https://www.ebi.ac.uk/pdbsum/2v42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v42 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI] Seems to modulate the activity of RpoE (sigma-E).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v42_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v42 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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An elegant network of signal transduction has evolved in the bacterial cell envelope to respond to environmental stress. It is initiated by sensing unfavourable and harmful changes in the periplasm. The stress signal is then transmitted by a controlled degradation of the transmembrane anti-sigma-factor RseA that leads to the activation of the alternative sigma factor sigma(E). The periplasmic protein RseB exerts a crucial role in modulating the stability of RseA. RseB from Escherichia coli has been crystallized and crystal structures were determined at 2.4 A and at 2.8 A resolution. The protein forms a homodimer, with the monomer composed of two domains. The large domain resembles an unclosed beta-barrel that is structurally remarkably similar to a protein family capable of binding the lipid anchor of lipoproteins. The small C-terminal domain, connected to the large domain by a partially unstructured loop, is responsible for interaction with RseA. On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
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===CRYSTAL STRUCTURE OF RSEB: A SENSOR FOR PERIPLASMIC STRESS RESPONSE IN E. COLI===
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The structure of RseB: a sensor in periplasmic stress response of E. coli.,Wollmann P, Zeth K J Mol Biol. 2007 Sep 28;372(4):927-41. Epub 2007 Jun 19. PMID:17692869<ref>PMID:17692869</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2v42" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17692869}}, adds the Publication Abstract to the page
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17692869 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17692869}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2V42 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V42 OCA].
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[[Category: Wollmann P]]
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[[Category: Zeth K]]
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==Reference==
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<ref group="xtra">PMID:17692869</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
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[[Category: Wollmann, P.]]
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[[Category: Zeth, K.]]
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[[Category: Regulator]]
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[[Category: Regulatory protein,lipoprotein binding,sensor for periplasmic stress]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:27:17 2009''
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Current revision

Crystal structure of RseB: a sensor for periplasmic stress response in E. coli

PDB ID 2v42

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