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1nj5

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{{Seed}}
 
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[[Image:1nj5.png|left|200px]]
 
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==Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to proline sulfamoyl adenylate==
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The line below this paragraph, containing "STRUCTURE_1nj5", creates the "Structure Box" on the page.
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<StructureSection load='1nj5' size='340' side='right'caption='[[1nj5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nj5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NJ5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P5A:5-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE'>P5A</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1nj5| PDB=1nj5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nj5 OCA], [https://pdbe.org/1nj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1nj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nj5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYP_METTH SYP_METTH] Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.[HAMAP-Rule:MF_01571]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/1nj5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nj5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to proline sulfamoyl adenylate===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12578991}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12578991 is the PubMed ID number.
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Kamtekar S]]
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{{ABSTRACT_PUBMED_12578991}}
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[[Category: Kennedy WD]]
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[[Category: Soll D]]
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==About this Structure==
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[[Category: Stathopoulos C]]
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1NJ5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ5 OCA].
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[[Category: Steitz TA]]
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[[Category: Wang J]]
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==Reference==
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<ref group="xtra">PMID:12578991</ref><references group="xtra"/>
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[[Category: Methanothermobacter thermautotrophicus]]
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[[Category: Proline--tRNA ligase]]
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[[Category: Kamtekar, S.]]
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[[Category: Kennedy, W D.]]
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[[Category: Soll, D.]]
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[[Category: Stathopoulos, C.]]
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[[Category: Steitz, T A.]]
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[[Category: Wang, J.]]
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[[Category: Protein-aminoacyladenylate complex class-ii trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:36:04 2009''
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Current revision

Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to proline sulfamoyl adenylate

PDB ID 1nj5

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