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2gcu

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{{Seed}}
 
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[[Image:2gcu.png|left|200px]]
 
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<!--
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==X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580==
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The line below this paragraph, containing "STRUCTURE_2gcu", creates the "Structure Box" on the page.
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<StructureSection load='2gcu' size='340' side='right'caption='[[2gcu]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gcu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GCU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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-->
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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{{STRUCTURE_2gcu| PDB=2gcu | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At1g53580 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcu OCA], [https://pdbe.org/2gcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gcu RCSB], [https://www.ebi.ac.uk/pdbsum/2gcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gcu ProSAT], [https://www.topsan.org/Proteins/CESG/2gcu TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ETHE1_ARATH ETHE1_ARATH]] Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Required for normal endosperm development in seed, and thereby also required for normal embryo development.<ref>PMID:22786886</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/2gcu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gcu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy.
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===X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580===
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Structure of an ETHE1-like protein from Arabidopsis thaliana.,McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:16929096<ref>PMID:16929096</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16929096}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2gcu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16929096 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_16929096}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Arath]]
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2GCU is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA].
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[[Category: Hydrolase]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Bingman, C A]]
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<ref group="xtra">PMID:16929096</ref><references group="xtra"/>
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[[Category: Bitto, E]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Structural genomic]]
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[[Category: Hydroxyacylglutathione hydrolase]]
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[[Category: McCoy, J G]]
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[[Category: Bingman, C A.]]
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[[Category: Phillips, G N]]
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[[Category: Bitto, E.]]
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[[Category: Wesenberg, G E]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Jr., G N.Phillips.]]
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[[Category: McCoy, J G.]]
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[[Category: Wesenberg, G E.]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
[[Category: Cesg]]
[[Category: Ethe1]]
[[Category: Ethe1]]
[[Category: Ethylmalonic encephalopathy]]
[[Category: Ethylmalonic encephalopathy]]
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[[Category: Protein structure initiative]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:36:44 2009''
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Current revision

X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580

PDB ID 2gcu

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