1jeq

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{{Seed}}
 
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[[Image:1jeq.png|left|200px]]
 
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==Crystal Structure of the Ku Heterodimer==
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The line below this paragraph, containing "STRUCTURE_1jeq", creates the "Structure Box" on the page.
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<StructureSection load='1jeq' size='340' side='right'caption='[[1jeq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JEQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jeq OCA], [https://pdbe.org/1jeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jeq RCSB], [https://www.ebi.ac.uk/pdbsum/1jeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jeq ProSAT]</span></td></tr>
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{{STRUCTURE_1jeq| PDB=1jeq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XRCC6_HUMAN XRCC6_HUMAN] Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.<ref>PMID:2466842</ref> <ref>PMID:8621488</ref> <ref>PMID:7957065</ref> <ref>PMID:9742108</ref> <ref>PMID:12145306</ref> <ref>PMID:20493174</ref> <ref>PMID:20383123</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/1jeq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jeq ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Ku Heterodimer===
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==See Also==
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*[[Ku protein|Ku protein]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11493912}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11493912 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11493912}}
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==About this Structure==
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1JEQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEQ OCA].
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==Reference==
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<ref group="xtra">PMID:11493912</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Corpina, R A.]]
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[[Category: Large Structures]]
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[[Category: Goldberg, J.]]
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[[Category: Corpina RA]]
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[[Category: Walker, J R.]]
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[[Category: Goldberg J]]
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[[Category: Alpha/beta domain]]
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[[Category: Walker JR]]
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[[Category: Beta barrel]]
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[[Category: Double-strand dna break repair]]
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[[Category: Helical c-terminal arm]]
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[[Category: Non-homologous end-joining]]
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[[Category: Sap domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:46:43 2009''
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Current revision

Crystal Structure of the Ku Heterodimer

PDB ID 1jeq

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