1af9
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1af9.png|left|200px]] | ||
| - | < | + | ==TETANUS NEUROTOXIN C FRAGMENT== |
| - | + | <StructureSection load='1af9' size='340' side='right'caption='[[1af9]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1af9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af9 OCA], [https://pdbe.org/1af9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af9 RCSB], [https://www.ebi.ac.uk/pdbsum/1af9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af9 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af9_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af9 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Tetanus toxin|Tetanus toxin]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Clostridium tetani]] | [[Category: Clostridium tetani]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Furey | + | [[Category: Furey WF]] |
| - | [[Category: Sax | + | [[Category: Sax M]] |
| - | [[Category: Schmidt | + | [[Category: Schmidt JJ]] |
| - | [[Category: Swaminathan | + | [[Category: Swaminathan S]] |
| - | [[Category: Umland | + | [[Category: Umland TC]] |
| - | [[Category: Wingert | + | [[Category: Wingert L]] |
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Current revision
TETANUS NEUROTOXIN C FRAGMENT
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