2alr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:13, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2alr.png|left|200px]]
 
-
<!--
+
==ALDEHYDE REDUCTASE==
-
The line below this paragraph, containing "STRUCTURE_2alr", creates the "Structure Box" on the page.
+
<StructureSection load='2alr' size='340' side='right'caption='[[2alr]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2alr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1alr 1alr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ALR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2alr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alr OCA], [https://pdbe.org/2alr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2alr RCSB], [https://www.ebi.ac.uk/pdbsum/2alr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2alr ProSAT]</span></td></tr>
-
{{STRUCTURE_2alr| PDB=2alr | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AK1A1_HUMAN AK1A1_HUMAN] Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).<ref>PMID:10510318</ref> <ref>PMID:11306097</ref> <ref>PMID:18276838</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/2alr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2alr ConSurf].
 +
<div style="clear:both"></div>
-
===ALDEHYDE REDUCTASE===
+
==See Also==
-
 
+
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15299353}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 15299353 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_15299353}}
+
-
 
+
-
==About this Structure==
+
-
2ALR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1alr 1alr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALR OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15299353</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: El-Kabbani, O.]]
+
[[Category: Large Structures]]
-
[[Category: Oxidoreductase]]
+
[[Category: El-Kabbani O]]
-
[[Category: Tim-barrel]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:56:36 2009''
+

Current revision

ALDEHYDE REDUCTASE

PDB ID 2alr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2alr"
Personal tools