2fji

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(New page: 200px<br /><applet load="2fji" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fji, resolution 2.40&Aring;" /> '''Crystal structure of...)
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[[Image:2fji.gif|left|200px]]<br /><applet load="2fji" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2fji, resolution 2.40&Aring;" />
 
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'''Crystal structure of the C-terminal domain of the exocyst subunit Sec6p'''<br />
 
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==Overview==
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==Crystal structure of the C-terminal domain of the exocyst subunit Sec6p==
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The exocyst is a conserved protein complex essential for trafficking, secretory vesicles to the plasma membrane. The structure of the C-terminal, domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the, C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity., The helical bundles appear to be evolutionarily related molecular, scaffolds that have diverged to create functionally distinct exocyst, proteins.
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<StructureSection load='2fji' size='340' side='right'caption='[[2fji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2fji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJI FirstGlance]. <br>
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2FJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [https://pdbe.org/2fji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB], [https://www.ebi.ac.uk/pdbsum/2fji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fji ProSAT]</span></td></tr>
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==Reference==
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</table>
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The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16699513 16699513]
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== Function ==
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[https://www.uniprot.org/uniprot/SEC6_YEAST SEC6_YEAST] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fji ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Munson M]]
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[[Category: Munson, M.]]
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[[Category: Sivaram MV]]
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[[Category: Sivaram, M.V.]]
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[[Category: exocyst complex]]
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[[Category: exocytosis]]
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[[Category: tandem helical bundles]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:35:15 2007''
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Current revision

Crystal structure of the C-terminal domain of the exocyst subunit Sec6p

PDB ID 2fji

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