1owd

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{{Seed}}
 
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[[Image:1owd.png|left|200px]]
 
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==Substituted 2-Naphthamidine inhibitors of urokinase==
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The line below this paragraph, containing "STRUCTURE_1owd", creates the "Structure Box" on the page.
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<StructureSection load='1owd' size='340' side='right'caption='[[1owd]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1owd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OWD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=497:6-[AMINO(IMINO)METHYL]-N-[(4R)-4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL]-2-NAPHTHAMIDE'>497</scene></td></tr>
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{{STRUCTURE_1owd| PDB=1owd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1owd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1owd OCA], [https://pdbe.org/1owd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1owd RCSB], [https://www.ebi.ac.uk/pdbsum/1owd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1owd ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/1owd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1owd ConSurf].
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<div style="clear:both"></div>
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===Substituted 2-Naphthamidine inhibitors of urokinase===
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14711304}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14711304 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_14711304}}
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==Disease==
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Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
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==About this Structure==
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1OWD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWD OCA].
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==Reference==
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<ref group="xtra">PMID:14711304</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: U-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Geyer, A.]]
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[[Category: Geyer A]]
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[[Category: Giranda, V L.]]
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[[Category: Giranda VL]]
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[[Category: Klinghofer, V.]]
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[[Category: Klinghofer V]]
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[[Category: Mantei, R.]]
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[[Category: Mantei R]]
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[[Category: McClellan, W.]]
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[[Category: McClellan W]]
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[[Category: Nienaber, V L.]]
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[[Category: Nienaber VL]]
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[[Category: Rockway, T W.]]
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[[Category: Rockway TW]]
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[[Category: Stewart, K.]]
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[[Category: Stewart K]]
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[[Category: Weitzberg, M.]]
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[[Category: Weitzberg M]]
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[[Category: Wendt, M D.]]
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[[Category: Wendt MD]]
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[[Category: Zhao, X.]]
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[[Category: Zhao X]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Plasminogen activation]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:57:42 2009''
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Current revision

Substituted 2-Naphthamidine inhibitors of urokinase

PDB ID 1owd

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