1h9v

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{{Seed}}
 
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[[Image:1h9v.png|left|200px]]
 
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==Human Fc-gamma-Receptor IIa (FcgRIIa), monoclinic==
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The line below this paragraph, containing "STRUCTURE_1h9v", creates the "Structure Box" on the page.
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<StructureSection load='1h9v' size='340' side='right'caption='[[1h9v]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9v OCA], [https://pdbe.org/1h9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9v RCSB], [https://www.ebi.ac.uk/pdbsum/1h9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9v ProSAT]</span></td></tr>
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{{STRUCTURE_1h9v| PDB=1h9v | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h9v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h9v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Once antigen is opsonised by IgG it is removed from the circulation by Fcgamma-receptor expressing cells. Fcgamma-receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. Previously solved structures of Fc-receptors reveal that the N-terminal two Ig-like domains are arranged in a steep angle forming a heart-shaped structure. The crystal structure of the FcgammaRIII/hIgG1-Fc-fragment demonstrated that the Fc-fragment is recognised through loops of the C-terminal receptor domain of the FcgammaRIII. As the overall structure of the FcRs and their Ig ligands are very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and FcepsilonRIalpha based on the FcgammaRIII/hIgG1-Fc-fragment structure. The obtained models are consistent with the observed biochemical data and may explain the observed specificity and affinities.
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===HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC===
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Molecular basis for immune complex recognition: a comparison of Fc-receptor structures.,Sondermann P, Kaiser J, Jacob U J Mol Biol. 2001 Jun 8;309(3):737-49. PMID:11397093<ref>PMID:11397093</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11397093}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1h9v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11397093 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11397093}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1H9V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA].
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==Reference==
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<ref group="xtra">PMID:11397093</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jacob, U.]]
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[[Category: Large Structures]]
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[[Category: Kaiser, J.]]
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[[Category: Jacob U]]
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[[Category: Sondermann, P.]]
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[[Category: Kaiser J]]
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[[Category: Fc-gamma-r]]
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[[Category: Sondermann P]]
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[[Category: Fc-receptor]]
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[[Category: Fcgr]]
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[[Category: Fcr]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:58:04 2009''
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Current revision

Human Fc-gamma-Receptor IIa (FcgRIIa), monoclinic

PDB ID 1h9v

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